Evidence map›Paper›PMID 40300782›Full record

ArticleJournal of the National Cancer Institute2025

The prevalence of parental cancer history and in vitro fertilization utilization.

Abby L Chen, Shufeng Li, Valerie L Baker, Philip J Lupo, Hazel B Nichols, Michael L Eisenberg, Barbara Luke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Abby L ChenDepartment of Urology, Stanford University School of Medicine, Stanford, CA, United States.ORCID 0000-0002-4985-2787
Shufeng LiDepartment of Urology, Stanford University School of Medicine, Stanford, CA, United States.
Valerie L BakerDepartment of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD, United States.ORCID 0000-0003-1762-7339
Philip J LupoDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.ORCID 0000-0003-0978-5863
Hazel B NicholsDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, United States.ORCID 0000-0003-0972-1560
Michael L EisenbergDepartment of Urology, Stanford University School of Medicine, Stanford, CA, United States.
Barbara LukeDepartment of Obstetrics, Gynecology and Reproductive Biology, Michigan State University College of Human Medicine, East Lansing, MI, United States.ORCID 0000-0002-0405-8133

Funding

A US-UK Collaborative Study of the Health of Children Born From In Vitro Fertilization: From Conception Through Young AdulthoodR01HD112081 · NICHD · EMORY UNIVERSITY · PI BARBARA JOAN LUKE, Philip Lupo · 2023 to 2026
$2.3M
National Institute of Child Health and Human DevelopmentNational Institutes of Health, USANICHD NIH HHS R01 HD112081NIH HHSNIH HHS R01 HD112081Philip Lupo and Barbara Luke, Multiple Principal InvestigatorsState Departments of Health
6 · The paper itself

Abstract

backgroundAdvances in cancer treatment have led to an increased number of survivors who may subsequently have children. We aim to describe the prevalence of a parental cancer history with and without the utilization of in vitro fertilization (IVF) in several states in the United States.

methodsThis study used data from IVF cycles resulting in live births reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System from 2004 to 2018. These were linked to birth certificates and cancer registries in 3 states (New York, Massachusetts, and North Carolina). For each IVF-conceived delivery, the subsequent 10 deliveries were used as the naturally conceived comparison group. A parent's cancer history was included if the diagnosis preceded the birth of the first child.

resultsThere were 814 658 births (82 544 IVF-conceived and 732 114 naturally conceived births) in our analysis. Among births conceived naturally, 0.5% of mothers and 0.4% of fathers had a cancer history compared with 1.2% of mothers and 1.8% of fathers among IVF-conceived births. The prevalence of cancer history increased over the study period (P ≤.004). The most common cancers among mothers were thyroid or endocrine (28.7%) and breast (12.2%) vs male genital (26.3%) and thyroid or endocrine (9.1%) among fathers. There were higher rates of male and female genital malignancies, female breast, and female lymphoid or hematopoietic cancers among parents who conceived with IVF (P < .001).

conclusionsOverall, 1.1% of all births and 3.0% of IVF-conceived births had at least 1 parent with a cancer history with an increasing prevalence over the study period, highlighting the importance of oncofertility programs.

Indexed as

Fertilization in VitroNeoplasmsParentsAdultFemaleHumansMaleMassachusettsNew YorkNorth CarolinaPregnancyPrevalenceRegistriesUnited States

Identifiers

PMID40300782
PMCPMC12229460

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.