Evidence map›Paper›PMID 40300765›Full record

ArticleBiochemistry2025

Biochemical Studies of a Cyanobacterial Halogenase Support the Involvement of a Dimetal Cofactor.

Michelle L Wang, Nathaniel R Glasser, Mrutyunjay A Nair, Carsten Krebs, J Martin Bollinger, Emily P Balskus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michelle L WangDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.ORCID 0000-0001-9836-3798
Nathaniel R GlasserDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.
Mrutyunjay A NairDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Carsten KrebsDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-3302-7053
J Martin BollingerDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0003-0751-8585
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.ORCID 0000-0001-5985-5714

Funding

Mechanisms of Mononuclear non-Heme-Iron EnzymesR35GM127079 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CARSTEN KREBS · 2018 to 2026
$3.8M
The biosynthesis of N-N bond-containing natural productsR01GM132564 · NIGMS · HARVARD UNIVERSITY · PI BALSKUS, EMILY PATRICIA · 2020 to 2023
$1.5M
NIGMS NIH HHS R01 GM132564NIGMS NIH HHS R35 GM127079
6 · The paper itself

Abstract

Halogenation is a prominent transformation in natural product biosynthesis, with over 5000 halogenated natural products known to date. Biosynthetic pathways accomplish the synthetic challenge of selective halogenation, especially at unactivated

Indexed as

Bacterial ProteinsCoenzymesCyanobacteriaOxidoreductasesHalogenationModels, MolecularMutagenesis, Site-DirectedBacterial ProteinsCoenzymesOxidoreductases

Identifiers

PMID40300765
PMCPMC12101540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.