Evidence map›Paper›PMID 40300738›Full record

ArticleHeart rhythm2026

Flecainide sensitizes conduction to hyponatremia through an ephaptic mechanism.

William P Adams, Gregory S Hoeker, Steven Poelzing

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. The electrophysiology of ventricular cell pairs.Pflugers Archiv : European journal of physiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

William P AdamsTranslational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Roanoke, Virginia; Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, Roanoke, Virginia.
Gregory S HoekerFralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, Roanoke, Virginia.
Steven PoelzingFralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, Roanoke, Virginia; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia. Electronic address: poelzing@vtc.vt.edu.

Funding

Role of the Extracellular Space as a Modulator of the Cardiac Gap Junction - Conduction Velocity RelationshipR01HL102298 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN · 2011 to 2020
$3.9M
Arrhythmia Mechanisms Modulated by Intercalated Disc Extracellular NanodomainsR01HL159097 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Steven Poelzing · 2023 to 2026
$2.5M
NHLBI NIH HHS R01 HL102298NHLBI NIH HHS R01 HL159097
6 · The paper itself

Abstract

backgroundStudies suggest that voltage-gated sodium channel (SC) loss-of-function (LoF), often through the use of SC blockers, such as tricyclic anti-depressants, some recreational drugs, and importantly, class 1c anti-arrhythmics, sensitizes cardiac conduction to hyponatremia. However, the mechanism driving conduction velocity (CV) sensitivity to sodium ion (Na

objectiveWe aimed to determine which mechanisms influence CV sensitivity to [Na

methodsCV was measured by optical mapping of Langendorff-perfused guinea pig hearts with either 145 or 120 mM [Na

resultsReducing [Na

conclusionSC LoF sensitizes conduction to changes in Na

Indexed as

FlecainideHeart Conduction SystemHyponatremiaAction PotentialsAnimalsAnti-Arrhythmia AgentsDisease Models, AnimalGuinea PigsMaleSodiumAnti-Arrhythmia AgentsFlecainideSodiumConductionElectrophysiologyEphaptic couplingFlecainide toxicityHyponatremiaOptical mapping

Identifiers

PMID40300738
PMCPMC12772518

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.