Evidence map›Paper›PMID 40300662›Full record

ArticleCancer letters2025

Cyst fluid proteins stratify malignant risk of intraductal papillary mucinous neoplasm of the pancreas.

Chunliang Liu, Amber Mosley, Ehsan Irajizad, Michele Yip-Schneider, Huangbing Wu, Whitney R Smith-Kinnaman, Thoa Tran, James P Long, Kim-Anh Do, Johannes Fahrmann and 4 more

Abstract read
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In one paragraph

Article in Cancer letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chunliang LiuDepartment of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN, USA; Department of Gastroenterology, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Amber MosleyDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Ehsan IrajizadDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Michele Yip-SchneiderDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Huangbing WuDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Whitney R Smith-KinnamanProteomics Core, Indiana University School of Medicine, Indianapolis, IN, USA.
Thoa TranDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
James P LongDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kim-Anh DoDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Johannes FahrmannDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
John M DeWittDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Samir HanashDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
C Max SchmidtDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA. Electronic address: maxschmi@iu.edu.
Jianjun ZhangDepartment of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN, USA; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA. Electronic address: JZ21@iu.edu.

Funding

Longitudinal Proteomic and Metabolomic Predictors of Pancreatic Cyst Malignant Progression and Early Stage Pancreatic CancerU01CA239522 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI SCHMIDT, CHRISTIAN MAXIMILLIAN, ZHANG, JIANJUN · 2021 to 2025
$3.3M
NCI NIH HHS U01 CA239522
6 · The paper itself

Abstract

Intraductal papillary mucinous neoplasm (IPMN) is the most common type of pancreatic cyst often incidentally detected in asymptomatic patients. The current consensus guidelines, largely based on imaging features, have high sensitivity but low specificity in differentiating benign from malignant IPMNs, leading to unnecessary surgeries. Discovering biomarkers is thus warranted to improve the preoperative risk stratification of IPMN. Pancreatic cyst fluid samples were obtained from patients with pathologically confirmed low-grade (n = 73) or high-grade/invasive (n = 18) IPMN. Global proteome quantitation was performed using liquid chromatography-tandem mass spectrometry. Differentially expressed proteins (DEPs) between the two groups were analyzed using Wilcoxon rank-sum test. 152 upregulated and 74 downregulated DEPs were discovered by comparing low-grade IPMN with high-grade/invasive IPMN (all p < 0.05). The enriched upstream regulators of these DEPs included let-7, miR-122, IL15, and FLT1 (p = 6.76 × 10

Indexed as

Biomarkers, TumorCarcinoma, Pancreatic DuctalCyst FluidPancreatic Intraductal NeoplasmsPancreatic NeoplasmsAgedFemaleHumansMaleMiddle AgedPancreatic CystProteomicsRisk AssessmentBiomarkers, TumorBiomarkersIntraductal papillary mucinous neoplasmPancreatic cancerPancreatic cyst fluidProteome

Identifiers

PMID40300662
PMCPMC13085096

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.