Evidence map›Paper›PMID 40300615›Full record

ArticleJournal of gastroenterology and hepatology2025

Increased Prevalence of Barrett's Esophagus in Taiwan: A Prospective Multicenter Study.

Fu-Jen Lee, Ming-Chang Tsai, Chien-Lin Chen, Ming-Wun Wong, Hsu-Heng Yen, Jeng-Yih Wu, Chen-Shuan Chung, Ping-Huei Tseng, Ying-Nan Tsai, Ming-Tsung Hsieh and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Fu-Jen LeeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Fu Jen Catholic University Hospital, New Taipei City, Taiwan.ORCID https://orcid.org/0000-0003-4503-3255
Ming-Chang TsaiSchool of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Chien-Lin ChenDepartment of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan.ORCID https://orcid.org/0000-0002-9084-8210
Ming-Wun WongDepartment of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan.
Hsu-Heng YenDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
Jeng-Yih WuFaculty of College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chen-Shuan ChungDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.ORCID https://orcid.org/0000-0001-9224-4958
Ping-Huei TsengDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-7483-7538
Ying-Nan TsaiDivision of Gastroenterology and Hepatology, E-Da Cancer Hospital, I-Shou University, Kaohsiung, Taiwan.
Ming-Tsung HsiehDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0003-4369-3380
Chi-Yang ChangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Fu Jen Catholic University Hospital, New Taipei City, Taiwan.ORCID https://orcid.org/0000-0002-6936-5142

Funding

Fu Jen Catholic University Hospital Grants PL-20200800X to Lee FJFu Jen Catholic University Hospital PL-20200800X
6 · The paper itself

Abstract

BACKGROUND AND

aimWith rising rates of esophageal adenocarcinoma (EAC) in Western countries, Barrett's esophagus (BE) has become a growing concern. The increasing prevalence of chronic gastroesophageal reflux disease (GERD) in Taiwan suggests a potential rise in BE cases as well. A 2007 large-scale study reported a BE prevalence of 1.06% in Taiwan. Our multicenter prospective study aims to evaluate the current prevalence of BE and identify key risk factors in this region.

methodWe assessed outpatients undergoing upper gastrointestinal endoscopy for various symptoms, obtaining biopsies from endoscopically suspected esophageal metaplasia (ESEM) at least 1 cm above the gastroesophageal junction. Quadrant biopsies were taken every 2 cm, with BE confirmed by histological evidence of specialized intestinal metaplasia.

resultsAmong 8697 subjects, the prevalence of BE was 2.6%. GERD symptoms, erosive esophagitis (EE), and hiatal hernia (HH) were present in 52.5%, 27.3%, and 7.85% of subjects, respectively. Of 751 with ESEM, 228 were diagnosed with BE, predominantly short-segment BE (78.1%). Multivariate analysis identified significant risk factors for BE: age > 50 (OR = 1.59), male gender (OR = 2.27), alcohol consumption (OR = 1.70), GERD symptoms (OR = 1.45), EE (OR = 1.94), and HH (OR = 2.49) (all p < 0.01).

conclusionThe prevalence of BE was identified as 2.6%, representing a significant increase compared with 2007. Significant risk factors include age more than 50, male gender, alcohol use, GERD symptoms, EE, and HH.

Indexed as

Barrett EsophagusAdultAgedAged, 80 and overAge FactorsAlcohol DrinkingFemaleGastroesophageal RefluxHernia, HiatalHumansMaleMiddle AgedMultivariate AnalysisPrevalenceProspective StudiesRisk FactorsBarrett's esophagusgastroesophageal reflux diseasehiatal herniaprevalencerisk factor

Identifiers

PMID40300615
PMCPMC12212406

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.