Evidence map›Paper›PMID 40300577›Full record

ArticleCerebrovascular diseases extra2025

Clinical Characteristics of Ischemic Stroke in Japanese Young Adults.

Tomoyuki Ohara, Naoki Makita, Jun Fujinami, Keiko Maezono-Kandori, Daiki Fukunaga, Eijirou Tanaka, Akihiro Fujii, Hidesato Takezawa, Naoki Tokuda, Takehiro Yamada and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebrovascular diseases extra, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tomoyuki OharaDepartment of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Naoki MakitaDepartment of Neurology, Kyoto Okamoto Memorial Hospital, Kumiyama, Japan.
Jun FujinamiDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Keiko Maezono-KandoriDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Daiki FukunagaDepartment of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Eijirou TanakaDepartment of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Akihiro FujiiDepartment of Neurology, Saiseikai Shigaken Hospital, Ritto, Japan.
Hidesato TakezawaDepartment of Neurology, Saiseikai Shigaken Hospital, Ritto, Japan.
Naoki TokudaDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Takehiro YamadaDepartment of Neurology and Stroke, Kyoto First Red Cross Hospital, Kyoto, Japan.
Shiori OguraDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Masahiro MakinoDepartment of Neurology, Kyoto Okamoto Memorial Hospital, Kumiyama, Japan.
Yoshinari NagakaneDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Keisuke ImaiDepartment of Neurology and Stroke, Kyoto First Red Cross Hospital, Kyoto, Japan.
Ikuko MizutaDepartment of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Toshiki MizunoDepartment of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere are limited data on the characteristics of stroke in young adults in East Asia including Japan. We aimed to clarify the clinical characteristics of ischemic stroke in Japanese young adults.

methodsWe prospectively enrolled ischemic stroke patients aged 18-50 years old who were admitted to 5 high-volume stroke centers within 14 days after onset between February 2018 and January 2023. We collected clinical and imaging data based on the study protocol and analyzed them for conventional and specific stroke risk factors, stroke etiology, and clinical outcome.

resultsWe enrolled 275 subjects (median age, 46 years; men, 71%; full-time workers, 75%; median NIHSS score at admission, 2 points). The major risk factors were dyslipidemia (59%), hypertension (49%), and smoking (32%). Hyperhomocysteinemia, migraine, and antiphospholipid syndrome were found in 21%, 11%, and 5%, respectively. The RNF213 p.R4810K variant was identified in 4.5%. The most common stroke etiologies were small vessel occlusion (26%) and arterial dissection (25%; intracranial in 20% and extracranial in 5%). The stroke recurrence rate was 5% at 3 months. Modified Rankin scale 0-1 at 3 months was observed in 76%, whereas 61% were able to return to their previous full-time work and 31% exhibited symptoms of depression.

conclusionsThe leading stroke etiologies in young adults in Japan were small vessel occlusion and intracranial arterial dissection, which differ from those observed in Western countries. Most young stroke patients had a favorable outcome, but some of them encountered problems relating to employment or mental health after their stroke.

Indexed as

Ischemic StrokeAdolescentAdultAge FactorsDisability EvaluationEast Asian PeopleFemaleHumansJapanMaleMiddle AgedPrognosisProspective StudiesRecurrenceReturn to WorkRisk AssessmentAcute ischemic strokeArterial dissectionOutcomeYoung adults

Identifiers

PMID40300577
PMCPMC12158410

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