SynthesisNeuroepidemiology2026
All-Cause and Cause-Specific Mortality in Parkinson's Disease: A Meta-Analysis.
Synthesis in Neuroepidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The trial behind it
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Who cites it
2 citing papers in PubMed.
- Type 2 Diabetes Risk among Incident Parkinson's Disease Patients: A 20-Year Retrospective Population-Based Cohort Study.Neuroepidemiology · 2026Article
- Suicidal behaviour and suicide mortality in Parkinson's disease: a nationwide register-based cohort study.BMJ neurology open · 2026Article
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Authors and funding
2 authors.
Funding
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Abstract
<p>Objectives: This study aimed to assess the overall and cause-specific standardized mortality ratios (SMRs) in patients diagnosed with Parkinson's disease (PD).
methodsA systematic review was conducted, focusing on studies that evaluated SMRs for all-causes and specific causes in PD patients compared to the general population. Searches were performed extensively in Medline, Embase, and Cochrane databases to compile relevant literature. A meta-analysis was subsequently conducted to evaluate all-cause, sex-specific, region-specific, and cause-specific SMRs in individuals with PD.
resultsTwenty-one studies including 26,114 PD patients and 10,247 deaths from 12 European, 4 Asian, 3 Oceanian, 1 North American, and 1 Middle Eastern country met the inclusion criteria. The overall SMR analysis revealed that PD patients exhibited a 1.617-fold higher risk of all-cause mortality compared to the general population (SMR 1.617, 95% confidence interval [CI] 1.295-2.020, p < 0.001). Region-specific analysis showed significant SMR increases across all regions. Sex-specific analysis indicated elevated SMRs for both women (SMR 1.702, 95% CI 1.426-2.033, p < 0.001) and men (SMR 1.588, 95% CI 1.365-1.848, p < 0.001). PD onset before 60 years of age was associated with a higher, albeit not statistically significant, SMR compared to onset after 60 (SMR 1.991, 95% CI 1.313-3.021 vs. SMR 1.589, 95% CI 1.109-2.277). Cause-specific analyses revealed significantly increased SMRs for pneumonia (SMR 3.414, 95% CI 2.227-5.234, p < 0.001), cerebrovascular accidents (CVAs) (SMR 1.484, 95% CI 1.048-2.102, p = 0.026), cardiovascular disease (SMR 1.449, 95% CI 1.156-1.816, p = 0.001), and suicide (SMR 2.049, 95% CI 1.383-3.035, p < 0.001), with no significant increase observed for cancer-related mortality.
conclusionThese findings highlight the increased mortality risk in PD patients, particularly due to causes such as pneumonia and CVA. </p>.
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