Evidence map›Paper›PMID 40300319›Full record

ArticleSocial science & medicine (1982)2025

Inflammation and minority stress: A moderated mediation model of childhood adversity and mental health in young men who have sex with men.

Laura H Dosanjh, Cynthia Franklin, Yessenia Castro, Bridget Goosby, Fiona N Conway, Frances A Champagne, Luis A Parra, Jeremy T Goldbach, Michele D Kipke

Abstract read
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In one paragraph

Article in Social science & medicine (1982), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Laura H DosanjhPopulation Research Center, University of Texas at Austin, United States. Electronic address: laurados@utexas.edu.
Cynthia FranklinSteve Hicks School of Social Work, University of Texas at Austin, United States.
Yessenia CastroSteve Hicks School of Social Work, University of Texas at Austin, United States.
Bridget GoosbyPopulation Research Center, University of Texas at Austin, United States; Department of Sociology, University of Texas at Austin, United States.
Fiona N ConwaySteve Hicks School of Social Work, University of Texas at Austin, United States.
Frances A ChampagneDepartment of Psychology, University of Texas at Austin, United States.
Luis A ParraDepartment of Systems, Populations and Leadership, University of Michigan, United States.
Jeremy T GoldbachDepartment of Social Work, Washington University, United States.
Michele D KipkeKeck School of Medicine, University of Southern California, United States.

Funding

Young Men of Color Who Have Sex with Men Cohort StudyU01DA036926 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI GOLDBACH, JEREMY THOMAS, KIPKE, MICHELE D. · 2015 to 2024
$23.3M
Training Program in Population StudiesT32HD007081 · NICHD · UNIVERSITY OF TEXAS AUSTIN · PI Aprile Dawn Benner, Abigail Mae Weitzman · 1985 to 2026
$6.8M
Scientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI MARK D. HAYWARD · 2017 to 2026
$5.2M
NICHD NIH HHS P2C HD042849NICHD NIH HHS T32 HD007081NIDA NIH HHS U01 DA036926
6 · The paper itself

Abstract

rationaleAdverse childhood experiences (ACEs) are linked to later anxiety and depression, and inflammation has been implicated as a mediating mechanism. Black and Latinx men who have sex with men (MSM) face higher prevalences of ACEs, anxiety, and depression compared to White, heterosexual peers. Understanding the links between ACEs and mental health is crucial to addressing these disparities.

methodsThis study used structural equation modeling to test moderated mediation models examining inflammation as a mediator of the relationship between ACEs and symptoms of anxiety/depression and minority stress as a moderator on the path between ACEs and inflammation. Data was from a community sample of Black and Latinx MSM (n = 246; mean age = 22.6).

resultsACEs were significantly associated with symptoms of anxiety (B = 0.414; p < 0.001) and depression (B = 0.346; p < 0.001), but inflammation did not show a significant mediating effect. Additionally, the interaction between ACEs and minority stress had no significant indirect effect on anxiety/depression.

conclusionsThese findings underscore the possibility that inflammation may not represent the global perturbations of stress processes after ACEs at younger ages, particularly among a relatively healthy sample of emerging adults.

Indexed as

Adverse Childhood ExperiencesHomosexuality, MaleInflammationMinority GroupsSexual and Gender MinoritiesStress, PsychologicalAdolescentAdultAnxietyBlack or African AmericanDepressionHispanic or LatinoHumansMaleMediation AnalysisMental Health

Identifiers

PMID40300319
PMCPMC13597027

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.