Evidence map›Paper›PMID 40300304›Full record

ArticleJACC. Advances2025

Noninvasive Hemodynamic Assessment by a Sensor Patch: The PATCHWRK (PortAble TeCHnology for Wireless caRdiomyopathy tracKing) Study.

Zak Loring, Nicholas B Bolus, F Brennan Torstrick, Danielle Wilson, Melissa Lefevre, Brett D Atwater, Anita Kelsey, Jonathan P Piccini

Abstract read
In one paragraph

Article in JACC. Advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zak LoringDivision of Cardiology, Department of Medicine, Duke University, Durham, North Carolina, USA; Duke Clinical Research Institute, Durham, North Carolina, USA. Electronic address: zloring@gmail.com.
Nicholas B BolusHuxley Medical Inc, Atlanta, Georgia, USA.
F Brennan TorstrickHuxley Medical Inc, Atlanta, Georgia, USA.
Danielle WilsonDivision of Cardiology, Department of Medicine, Duke University, Durham, North Carolina, USA.
Melissa LefevreDivision of Cardiology, Department of Medicine, Duke University, Durham, North Carolina, USA.
Brett D AtwaterInova Schar Heart and Vascular, Falls Church, Virginia, USA.
Anita KelseyDivision of Cardiology, Department of Medicine, Duke University, Durham, North Carolina, USA.
Jonathan P PicciniDivision of Cardiology, Department of Medicine, Duke University, Durham, North Carolina, USA; Duke Clinical Research Institute, Durham, North Carolina, USA.

Funding

Neurocognition and Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)R01AG074185 · NIA · DUKE UNIVERSITY · PI MATHEW, JOSEPH P, PICCINI, JONATHAN PAUL · 2021 to 2025
$3.7M
Non-invasive hemodynamic sensor patch for remote, early detection and prevention of heart failure with left bundle branch blockR43HL158282 · NHLBI · HUXLEY MEDICAL, INC. · PI TORSTRICK, BRENNAN · 2021 to 2021
$256k
NHLBI NIH HHS R43 HL158282NIA NIH HHS R01 AG074185
6 · The paper itself

Abstract

backgroundEchocardiographic timing intervals provide prognostic information in patients with preclinical cardiac dysfunction. Reduced diastolic filling time (DFT) identifies left bundle branch block patients at risk for cardiomyopathy. The need for specialized equipment limits the utility of echocardiography (echo) for longitudinal assessment.

objectivesThe purpose of this study was to evaluate a multimodal sensor patch's (SANSA) assessment of DFT, pre-ejection period (PEP), and left ventricular ejection time (LVET).

methodsFifty patients undergoing echo were prospectively enrolled and had simultaneous SANSA patch recording and echo. Timing intervals were analyzed using continuous wave, pulsed wave, and tissue Doppler imaging. SANSA electrocardiogram, seismocardiogram, and phonocardiogram data were independently analyzed to identify valve openings/closures for DFT, PEP, and LVET estimation. Agreement between echo and SANSA estimates was assessed using intraclass correlation coefficients (ICC) and compared with agreement between echo views.

resultsForty-six of the 50 patients (92%) had analyzable data. The mean ejection fraction was 53% ± 8%; 13 patients (26%) had left bundle branch block. Echo-estimated mean DFT, PEP, and LVET were 416 ± 139 milliseconds (ms), 108 ± 32 ms, and 300 ± 36 ms, respectively. SANSA-estimated DFT, PEP, and LVET were 431 ± 135 ms, 91 ± 35 ms, and 285 ± 43 ms, respectively. The ICC for SANSA vs echo was 0.92 for DFT, 0.74 for PEP, and 0.76 for LVET. The ICC for tissue Doppler imaging vs pulsed wave estimates within the same patients was 0.93 for DFT, 0.83 for PEP, and 0.69 for LVET.

conclusionsSANSA patch monitoring accurately measures key cardiac timing intervals to within the variability observed between echo views. As these intervals have prognostic value, SANSA-based longitudinal monitoring may facilitate early cardiomyopathy detection.

Indexed as

diastolic functionechocardiographyleft bundle branch blockpatch sensor

Identifiers

PMID40300304
PMCPMC12242580

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.