Evidence map›Paper›PMID 40299900›Full record

ArticlePloS one2025

In vitro activity of seven antifungal agents against Fusarium oxysporum and expression of related regulatory genes.

Dafeng Xu, Kun Wang, Tingchun Li, Jingjing Wang, Shiji Wang, Fanna Kong, Jie Dai, Yuguo Liu, Banfeng Ruan, Benguo Zhou

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Interactions BetweenMicroorganisms · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dafeng XuInstitute of Industrial Crops, Anhui Academy of Agricultural Sciences, Hefei, China.ORCID 0009-0003-2506-4318
Kun WangSchool of Biological Food and Environment, Hefei University, Hefei, China.
Tingchun LiInstitute of Industrial Crops, Anhui Academy of Agricultural Sciences, Hefei, China.
Jingjing WangHuainan Academy of Agricultural Sciences, Huainan, China.
Shiji WangInstitute of Industrial Crops, Anhui Academy of Agricultural Sciences, Hefei, China.
Fanna KongInstitute of Industrial Crops, Anhui Academy of Agricultural Sciences, Hefei, China.
Jie DaiHuainan Academy of Agricultural Sciences, Huainan, China.
Yuguo LiuHachikō Legend Culture & Tourism Group, Huainan, China.
Banfeng RuanSchool of Biological Food and Environment, Hefei University, Hefei, China.
Benguo ZhouInstitute of Industrial Crops, Anhui Academy of Agricultural Sciences, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fusarium oxysporum (F. oxysporum) is one of the main pathogenic fungus causing maize ear rot. In this study, the aims were to screen highly effective pesticides for F. oxysporum, reduce peasants' misunderstandings about pesticide application, improve disease control levels, and enhance economic efficiency. The toxicity of seven fungicides (carbendazim, pyraclostrobin, epoxiconazole, tricyclazole, azoxystrobin, difenoconazole, quintozene) on F. oxysporum were determined by the mycelium growth rate and the spore germination method, and single and compound fungicides with effective inhibitory effects on mycelial growth were screened. The RT-qPCR method was used to detect the expression levels of chitin synthetase V (ChsV), folate uptake block T (FUBT), superoxide dismutase (SOD), and peroxidase dismutase (POD) genes in pathogenic bacteria treated with the selected agents and combination of fungicides. The results showed that all seven fungicides had inhibitory effects on mycelial growth hyphae and spore germination of F. oxysporum. Epoxiconazole had the strongest inhibitory effect on mycelium growth and spore germination of F. oxysporum, with effective concentrations (EC50) of 0.047 and 0.088 μg/mL, respectively. The combination of pyraclostrobin and difenoconazole (P&D, combined at a mass ratio of 7:3) had the best inhibitory effect, with an EC50 of 0.094 μg/mL and an SR of 2.650. Epoxiconazole and the combination P&D could inhibit mycelial growth and spore germination by down-regulating ChsV, FUBT, and POD, causing oxidative stress in F. oxysporum, and reducing the occurrence of maize ear rot.

Indexed as

Antifungal AgentsFungicides, IndustrialFusariumGene Expression Regulation, FungalAminoimidazole CarboxamideBenzimidazolesCarbamatesChitin SynthaseDioxolanesEpoxy CompoundsFungal ProteinsMyceliumPlant DiseasesPyrimidinesSpores, FungalStrobilurinsAminoimidazole CarboxamideAntifungal AgentsazoxystrobinBenzimidazolesCarbamatescarbendazimChitin SynthasedifenoconazoleDioxolanesepoxiconazoleEpoxy CompoundsFungal ProteinsFungicides, IndustrialPyrimidinesStrobilurinsSuperoxide DismutaseTriazoles

Identifiers

PMID40299900
PMCPMC12040100

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.