Evidence map›Paper›PMID 40299876›Full record

ArticlePloS one2025

Chronic active and chronic inactive hepatitis B virus infection: Comparative study of genetic polymorphism and blood profile measures.

Khalid Elyass Awadelkarim, Najem Aldin M Osman, A M S Eleragi, Abdelsalam M A Nail, Nadir Abuzeid, Mohamed E Elangeeb, Elsadig Mohamed Ahmed, Jaber Ahmed Al-Faifi, Abdullah Alhalafi, Ahmed S Doghish and 1 more

Abstract readComparative Study
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Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Khalid Elyass AwadelkarimDepartment of Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Khartoum, Sudan.
Najem Aldin M OsmanDepartment of Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Khartoum, Sudan.ORCID 0000-0002-0763-0334
A M S EleragiDepartment of Microorganisms and Clinical Parasitology, College of Medicine, University of Bisha, Bisha, Saudi Arabia.
Abdelsalam M A NailDepartment of Internal Medicine, Faculty of Medicine, Omdurman Islamic University, Khartoum, Sudan.
Nadir AbuzeidDepartment of Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Khartoum, Sudan.
Mohamed E ElangeebDepartment of Basic Medical Sciences, College of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia.ORCID 0000-0002-7191-1675
Elsadig Mohamed AhmedDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia.
Jaber Ahmed Al-FaifiDepartment of Child Health, College of Medicine, University of Bisha, Bisha, Saudi Arabia.
Abdullah AlhalafiDepartment of Family and Community Medicine, College of Medicine, University of Bisha, Bisha, Saudi Arabia.
Ahmed S DoghishDepartment of Biochemistry, Faculty of Pharmacy, Badr University in Cairo, Cairo, Egypt.ORCID 0000-0002-0136-7096
Osama A MohammedDepartment of Pharmacology, College of Medicine, University of Bisha, Bisha, Saudi Arabia.ORCID 0000-0001-9712-9609

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHepatitis B virus (HBV) is a significant cause of chronic hepatitis, leading to liver complications such as cirrhosis and hepatocellular carcinoma. Toll-like receptors (TLRs) are critical in the immune response to HBV. This study investigates the TLR3 1377 C/T polymorphism's association with clinical outcomes in chronic hepatitis B patients. MATERIALS AND

methodsA case-control study included 136 participants (66 cases and 70 controls). The patients were categorized as having chronic active or inactive hepatitis B based on serological, biochemical, and molecular parameters. TLR3 1377 C/T polymorphism was analyzed using PCR-RFLP. The correlation between TLR3 genotypes, HBeAg status, liver enzyme levels (ALT and AST), and symptomatic presentation was assessed.

resultsAmong the 66 cases, the CC genotype was more frequent in males with chronic active hepatitis (14 males, 5 females), but no significant gender-based difference was observed in genotype distribution. A significant association was found between the CC genotype and symptomatic presentation in chronic active cases (P = 0.015). However, no significant association was detected between TLR3 genotypes and HBeAg status (P > 0.05). Elevated ALT and AST levels were more prevalent in chronic active cases.

conclusionsThe TLR3 1377 C/T polymorphism, particularly the CC genotype, may influence the clinical presentation of chronic hepatitis B, particularly in symptomatic cases. However, its impact on HBeAg status and overall chronicity appears limited. Further studies are needed to clarify the role of TLR3 polymorphisms in HBV pathogenesis and their potential as therapeutic targets.

Indexed as

Hepatitis B, ChronicHepatitis B virusPolymorphism, Single NucleotideToll-Like Receptor 3AdultAlanine TransaminaseAspartate AminotransferasesCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHepatitis B e AntigensHumansMaleMiddle AgedAlanine TransaminaseAspartate AminotransferasesHepatitis B e AntigensTLR3 protein, humanToll-Like Receptor 3

Identifiers

PMID40299876
PMCPMC12040076

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