Evidence map›Paper›PMID 40299776›Full record

ArticleDrug and alcohol review2025

Elucidating the acute effects of medically prescribed oral and vaporised delta-9-tetrahydrocannabinol on cognitive functions important for driving.

Kayla B Stefanidis, Carla Schiemer, Taren Mieran, Andrew Hill, Mark S Horswill, Mathew J Summers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kayla B StefanidisMAIC/UniSC Road Safety Research Collaboration, University of the Sunshine Coast, Sippy Downs, Australia.ORCID 0000-0002-0559-1810
Carla SchiemerMAIC/UniSC Road Safety Research Collaboration, University of the Sunshine Coast, Sippy Downs, Australia.
Taren MieranMAIC/UniSC Road Safety Research Collaboration, University of the Sunshine Coast, Sippy Downs, Australia.ORCID 0009-0006-1160-0521
Andrew HillMinerals Industry Safety and Health Centre, Sustainable Minerals Institute, The University of Queensland, Brisbane, Australia.
Mark S HorswillSchool of Psychology, The University of Queensland, Brisbane, Australia.
Mathew J SummersDiscipline of Psychology, School of Health, University of the Sunshine Coast, Sippy Downs, Australia.

Funding

This research was funded by the Motor Accident Insurance Commission. The funders did not have any role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript
6 · The paper itself

Abstract

introductionThis program of research investigated the acute effects of orally ingested (Study 1) and vaporised (Study 2) cannabis containing delta-9-tetrahydrocannabinol (THC) on cognitive functions relevant for driving in two samples of medicinal cannabis patients (Study 1 N = 41 oral users; Study 2 N = 37 flower users).

methodParticipants completed counterbalanced baseline (no cannabis) and cannabis consumption (post-cannabis) appointments scheduled approximately 1 week apart. During each session, participants were administered a cognitive battery assessing information processing speed, sustained and divided attention, inhibitory control and mental flexibility. In the post-cannabis condition, the battery was completed 90 min after consuming one dose of cannabis oil (Study 1) or 15 min after vaporising one dose of cannabis flower (Study 2).

resultsIn both samples, acute cannabis oil and flower administration did not induce a change in information processing speed, divided and sustained attention, or inhibitory control performance (after excluding participants with a positive drug indication at the start of either session), highlighting the moderating role of tolerance. However, significant reductions in TMT B performance were observed. Further, TMT ratio was significantly reduced post consumption of cannabis oil. DISCUSSION AND

conclusionsTMT B may be sensitive to acute cannabis consumption in medicinal cannabis patients. However, further research is needed to determine the nature and duration of these effects, and whether such effects vary depending on the population studied (e.g., regular vs. new users).

Indexed as

Automobile DrivingCognitionDronabinolMedical MarijuanaAdministration, InhalationAdministration, OralAdultAttentionFemaleHumansMaleMiddle AgedYoung AdultDronabinolMedical Marijuanacannabiscognitiondelta‐9‐tetrahydrocannabinolneuropsychologyTHC

Identifiers

PMID40299776
PMCPMC12117310

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.