Evidence map›Paper›PMID 40299750›Full record

ArticleThe Journal of clinical investigation2025

Widespread tissue distribution of transcriptionally active, clonally expanded HIV-1 proviruses despite suppressive antiretroviral therapy.

Hiromi Imamichi, Ven Natarajan, Francesca Scrimieri, Mindy Smith, Yunden Badralmaa, Marjorie Bosche, Jack Hensien, Thomas Buerkert, Weizhong Chang, Brad Sherman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hiromi ImamichiClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Ven NatarajanFrederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Francesca ScrimieriFrederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Mindy SmithClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Yunden BadralmaaFrederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Marjorie BoscheFrederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Jack HensienClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Thomas BuerkertClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Weizhong ChangFrederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Brad ShermanFrederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Kanal SinghClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
H Clifford LaneClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence of HIV-1 associated DNA and RNA can be found in multiple tissues despite adequate anti-retroviral therapy.

Indexed as

Anti-Retroviral AgentsHIV-1HIV InfectionsProvirusesTranscription, GeneticAdultDNA, ViralFemaleHumansMaleRNA, ViralAnti-Retroviral AgentsDNA, ViralRNA, ViralAIDS/HIVInfectious diseaseMolecular biologyMolecular pathologyVirology

Identifiers

PMID40299750
PMCPMC12165783

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.