ArticleJournal of the American Chemical Society2025
Avoidance of Secondary Carbocations, Unusual Deprotonation, and Nonstatistical Dynamic Effects in the Cyclization Mechanism of Tetraisoquinane.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Sequence-guided engineering of a bacterial diterpene synthase induces further cyclization.ACS catalysis · 2026Article
- Article
- Xeniaphyllane-Type Diterpenoids from the Soft CoralJournal of natural products · 2026Article
- Sclerofish A and B: Two Pairs of Enantiomeric Diterpenoids Featuring a 4/7/6-Fused Tricyclic Scaffold from the Soft CoralThe Journal of organic chemistry · 2026Article
- Development of Potent and Cell Active 5-Azaindole-Based Tau Tubulin Kinase Inhibitors.bioRxiv : the preprint server for biology · 2026Article
- Biosynthetic formation of the 6/7/5-odyverdiene diterpenes via a 6/10-ACS catalysis · 2026Article
- A Single Residue Switch Controls Isomer Selectivity in the Myxobacterial Isobonnadiene Synthase.Organic letters · 2026Article
- Generation [via Tetradehydro-Diels-Alder Reactions] and Reactivity of 6-Fluorocyclohexa-1,2,4-triene Intermediates.Organic letters · 2025Article
- Discovery of UbiA-Type Cyathane Synthases in Bacteria.ACS catalysis · 2025Article
- Biosynthesis of the Red Algal Diterpene Peyssonnosol in Bacteria.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The complexity and versatility of terpene cyclization reactions contribute to the wide variety of functions and properties that terpenoid compounds exhibit in nature. The management of reactive carbocations over the course of the reaction to ultimately arrive at a particular carbon fragment connectivity and stereochemistry is no small feat. Bacteria possess a variety of TSs that generate diverse polycyclic terpene skeletons; however, terpenoids in myxobacteria are especially rare. Here, we report the first mechanistic study of tetraisoquinene biosynthesis from TiqS, a diterpene synthase from
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