Evidence map›Paper›PMID 40299692›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Calcium-activated chloride channel TMEM16A opens via pi-helical transition in transmembrane segment 4.

Andrei Y Kostritskii, Yulia Kostritskaia, Natalia Dmitrieva, Tobias Stauber, Jan-Philipp Machtens

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrei Y KostritskiiInstitute of Biological Information Processing (IBI-1), Molekular- und Zellphysiologie, Forschungszentrum Jülich, Jülich 52428, Germany.ORCID 0000-0001-5890-4123
Yulia KostritskaiaInstitute for Molecular Medicine, MSH Medical School Hamburg, Hamburg 20457, Germany.ORCID 0000-0001-9933-2918
Natalia DmitrievaInstitute of Biological Information Processing (IBI-1), Molekular- und Zellphysiologie, Forschungszentrum Jülich, Jülich 52428, Germany.ORCID 0009-0000-1371-553X
Tobias StauberInstitute for Molecular Medicine, MSH Medical School Hamburg, Hamburg 20457, Germany.ORCID 0000-0003-0727-6109
Jan-Philipp MachtensInstitute of Biological Information Processing (IBI-1), Molekular- und Zellphysiologie, Forschungszentrum Jülich, Jülich 52428, Germany.ORCID 0000-0003-1673-8571

Funding

Deutsche Forschungsgemeinschaft (DFG) MA 7525/1-2Deutsche Forschungsgemeinschaft (DFG) MA 7525/2-1
6 · The paper itself

Abstract

TMEM16A is a Ca

Indexed as

Anoctamin-1CalciumChloride ChannelsIon Channel GatingNeoplasm ProteinsAnimalsHEK293 CellsHumansMolecular Dynamics SimulationMutationPatch-Clamp TechniquesProtein Conformation, alpha-HelicalProtein Structure, SecondaryANO1 protein, humanAnoctamin-1CalciumChloride ChannelsNeoplasm Proteinschloride channelelectrophysiologygatingmolecular dynamicsTMEM16A

Identifiers

PMID40299692
PMCPMC12067253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.