Evidence map›Paper›PMID 40299540›Full record

GuidelineInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2025

FIGO guideline on liver disease and pregnancy.

Melanie Nana, Virna Medina, Cynthia Maxwell, Ciara McCormick, Gloria Taliani, Ulrich Beuers, Deborah Money, Bo Jacobsson, Anil Kapur, Titus Beyuo and 14 more

Abstract readPractice Guideline
In one paragraph

Guideline in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. FIGO guideline on liver disease and pregnancy.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Guideline
  2. Article
  3. Article
  4. Preexisting Liver Disease and Pregnancy: Optimizing Care to Optimize Outcomes.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Intrahepatic cholestasis of pregnancy.Nature reviews. Disease primers · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Melanie NanaDepartment of Women and Childrens' Health, King's College London, London, UK.
Virna MedinaDepartment of Obstetrics and Gynecology, Faculty of Health, Universidad del Valle, Clínica Imbanaco Quirón Salud, Universidad Libre, Cali, Colombia.
Cynthia MaxwellMaternal Fetal Medicine, Sinai Health and Women's College Hospital University of Toronto, Ontario, Canada.
Ciara McCormickUCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Gloria TalianiDepartment of Infectious and Tropical Diseases, La Sapienza University of Rome, Rome, Italy.
Ulrich BeuersDepartment of Gastroenterology & Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location AMC, Amsterdam, The Netherlands.
Deborah MoneyDepartment of Obstetrics and Gynecology, The University of British Columbia, Vancouver, Canada.
Bo JacobssonDepartment of Obstetrics and Gynecology, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden.
Anil KapurWorld Diabetes Foundation, Bagsværd, Denmark.
Titus BeyuoDepartment of Obstetrics and Gynaecology, University of Ghana Medical School, Accra, Ghana.
Francisco RuilobaInstituto Nacional de Perinatologia, Department of Obstetrics and Gynecology, Mexico City, Mexico.
Graeme SmithDepartment of Obstetrics & Gynecology, Kingston Health Sciences Centre, Queen's University, Kingston, Ontario, Canada.
Lina BergmanDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Sharleen O'ReillyUCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Patrick O'BrienInstitute for Women's Health, University College London, London, UK.
Mark HansonInstitute of Developmental Sciences, University Hospital Southampton, Southampton, UK.
Mary RosserDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York, USA.
Claudio SosaDepartment of Obstetrics and Gynecology, Pereira-Rossell Hospital, School of Medicine, University of the Republic, Montevideo, Uruguay.
Sumaiya AdamDepartment of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Valerie GuintoMaternal-Fetal Medicine, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Liona PoonDepartment of Obstetrics and Gynaecology, Prince of Wales Hospital, the Chinese University of Hong Kong, Hong Kong, China.
Fionnuala McAuliffeUCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.ORCID https://orcid.org/0000-0002-3477-6494
Catherine WilliamsonDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
FIGO Committee on Impact of Pregnancy on Long‐term Health, FIGO Committee on Infections during Pregnancy and the FIGO Division of Maternal and Newborn Health

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The number of women entering pregnancy with chronic liver disease is rising. Gestational liver disorders affect 3% of the pregnant population. Both can be associated with significant maternal and fetal morbidity and mortality. European guidance has recently been published to inform management. This FIGO (the International Federation of Gynecology & Obstetrics) guideline aims to use the latest evidence to inform practice relevant to a global population. The immediate past and present chairs of FIGO's Committee on the Impact of Pregnancy on Long-term Health invited the Chair of the European guideline, alongside two trainees with an interest in liver disorders in pregnancy, to develop a guideline relevant to a global audience, thus serving the real-world population and fulfilling FIGO's ambition to enhance their global voice for women's health. Experts in the field with experience in managing liver disorders in pregnancy from a diverse selection of continents helped to develop a guideline. The guideline includes the most common pre-existing and gestational liver disorders. Evidence-based best practice recommendations are summarized in addition to pragmatic recommendations. Printable tables/figures are included in the guideline for ease of use. These include a table of normal ranges of commonly used blood tests, a table outlining safety of investigations, and a table of delivery considerations relevant to a global audience. Figures designed to summarize each section of the guideline and the multidisciplinary approach to managing liver disorders in pregnancy are also included. This guideline incorporates guidance for a global audience aimed at improving the management of women with pre-existing and new liver disease in pregnancy.

Indexed as

Liver DiseasesPregnancy ComplicationsFemaleHumansPregnancyguidelineliver diseasepregnancy

Identifiers

PMID40299540
PMCPMC12177296

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.