Evidence map›Paper›PMID 40299395›Full record

ArticleBiomedicines2025

Metabolic and Structural Consequences of GM3 Synthase Deficiency: Insights from an HEK293-T Knockout Model.

Elena Chiricozzi, Giulia Lunghi, Manuela Valsecchi, Emma Veronica Carsana, Rosaria Bassi, Erika Di Biase, Dorina Dobi, Maria Grazia Ciampa, Laura Mauri, Massimo Aureli and 4 more

Abstract read
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elena ChiricozziDepartment of Medical Biotechnology and Translational Medicine, Università Degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0001-7431-9207
Giulia LunghiDepartment of Medical Biotechnology and Translational Medicine, Università Degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0002-3099-3395
Manuela ValsecchiDepartment of Medical Biotechnology and Translational Medicine, Università Degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0003-4532-5979
Emma Veronica CarsanaDepartment of Medical Biotechnology and Translational Medicine, Università Degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0003-1486-550X
Rosaria BassiDepartment of Medical Biotechnology and Translational Medicine, Università Degli Studi di Milano, 20054 Segrate, Italy.
Erika Di BiaseThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Dorina DobiDepartment of Medical Biotechnology and Translational Medicine, Università Degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0002-9536-5912
Maria Grazia CiampaDepartment of Medical Biotechnology and Translational Medicine, Università Degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0002-4026-1067
Laura MauriDepartment of Medical Biotechnology and Translational Medicine, Università Degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0002-4194-4804
Massimo AureliDepartment of Medical Biotechnology and Translational Medicine, Università Degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0003-1916-2440
Kei-Ichiro InamoriDivision of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan.ORCID 0000-0002-5947-3633
Jin-Ichi InokuchiForefront Research Center, Graduate School of Science, Osaka University, Toyonaka 565-0871, Japan.
Sandro SonninoDepartment of Medical Biotechnology and Translational Medicine, Università Degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0001-8180-5908
Maria FazzariDepartment of Medical Biotechnology and Translational Medicine, Università Degli Studi di Milano, 20054 Segrate, Italy.ORCID 0000-0001-7034-9820

Funding

Fondi Tariffario RV_TAR16SSONN_MItalian Ministry of University and Research (MUR) PRIN202223ECHIR_01Milano University PSR2022_DIP_003FAZZARI-SAVINONext Generation EU Missione 4 Componente 1 the project n. 2022FLAZEC_001, CUP G53D23004490006
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

gangliosidesGM3 synthase deficiencylysosomesneurodegenerationplasma membrane

Identifiers

PMID40299395
PMCPMC12024672

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.