Evidence map›Paper›PMID 40299312›Full record

ArticleProtein science : a publication of the Protein Society2025

Structure and inhibition of diaminopimelic acid epimerase by slow-binding α-methyl amino acids.

Tess Lamer, Pu Chen, Karizza Catenza, Ilia Perov, Bethan L, Yu-Ting Hsiao, Tayla J Van Oers, M Joanne Lemieux, John C Vederas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tess LamerDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-1511-4540
Pu ChenDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-0434-6346
Karizza CatenzaDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0009-0008-3571-0535
Ilia PerovDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Bethan LDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0001-5014-3251
Yu-Ting HsiaoDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Tayla J Van OersDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0009-0006-2314-560X
M Joanne LemieuxDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-4745-9153
John C VederasDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-2996-0326

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Ritimukta Sarangi · 2020 to 2026
$43.3M
Natural Sciences and Engineering Research Council of CanadaNIGMS NIH HHS P30 GM133894
6 · The paper itself

Abstract

Cofactor-independent racemases and epimerases produce D-amino acids from their L-isomers for a variety of biological processes. These enzymes operate via an unusual mechanism that relies on an active site cysteine thiolate (pK

Indexed as

Amino Acid IsomerasesAmino AcidsAnabaenaBacterial ProteinsEnzyme InhibitorsCatalytic DomainCrystallography, X-RayModels, MolecularAmino Acid IsomerasesAmino AcidsBacterial Proteinsdiaminopimelate epimeraseEnzyme Inhibitorsantibioticcofactor‐independentcrystal structureDAP epimeraseDapFdiaminopimelic acidenzyme mechanisminhibitorlysine biosynthesisprotein biochemistry

Identifiers

PMID40299312
PMCPMC12039745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.