Evidence map›Paper›PMID 40299300›Full record

SynthesisMolecular neurobiology2025

Integrative Approaches Identify Genetic Determinants of Levodopa Induced Dyskinesia.

Ying Wan, Lu Rong, Qingyuan Li, Suzhi Liu, Wentao Li, Min Ye, Weifeng Luo, Anmu Xie, Jingsong Shao, Dengjun Guo and 3 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ying Wan *Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lu Rong *Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qingyuan LiCAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Shandong Province, Qingdao, China.
Suzhi LiuDepartment of Neurology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Zhejiang Province, Linhai, China.
Wentao LiDepartment of Neurology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Min YeDepartment of Neurology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Jiangsu Province, Nanjing, China.
Weifeng LuoDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Jiangsu Province, Suzhou, , China.
Anmu XieDepartment of Neurology, The Affiliated Hospital of Qingdao University, Shandong Province, Qingdao, , China.
Jingsong ShaoDepartment of Neurology, Shaoxing Hospital of Traditional Chinese Medicine, Zhejiang Province, Shaoxing, China.
Dengjun GuoDepartment of Neurology, Tongde Hospital of Zhejiang Province, Zhejiang Province, Hangzhou, China.
Xiaoping ZhangDepartment of Neurology, The First People's Hospital of Lin'an District, Zhejiang Province, Hangzhou, China.
Kezhong ZhangDepartment of Neurology, The First Affiliated Hospital With Nanjing Medical University, Jiangsu Province, Nanjing, China.
Zhenguo LiuDepartment of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. liuzhenguo@xinhuamed.com.cn.

Funding

Innovative research team of high-level local universities in Shanghai SHSMU-ZDCX20211901Medical Engineering Cross Research Fund of Shanghai Jiao Tong University YG2023ZD12Medical Engineering Cross Research Fund of University of Shanghai for Science and Technology 2023GD-XH06ZNational Key Research and Development Program of China 2017YFC1310300Projects of National Science Foundation of China 81974173Projects of the Shanghai Committee of Science and Technology 22Y11904100Shanghai Demonstration Project of Cooperative Diagnosis and Treatment for Major Difficult Diseases with integrative modern and traditional Chinese medicine ZY(2021-2023)-0207-01-03
6 · The paper itself

Abstract

Levodopa induced dyskinesia (LID) is a serious side effect of levodopa treatment in Parkinson's disease (PD), with limited interventions. Understanding the genetic impact on LID would help inform future intervention studies. We performed integrative genomic analysis approaches to identify the genetic determinants of LID in a Chinese multi-center prospective, observational PD cohort. In this cohort, 46 of 315 PD patients developed LID during 2.5 years of follow-up. First, we performed a genome-wide association study (GWAS) in this cohort, followed by a meta-analysis integrating our GWAS summary data with additional data of European ancestry. Both GWAS analyses identified the Bromodomain Containing 3 (BRD3) as a LID susceptibility gene (P < 5 × 10

Indexed as

Dyskinesia, Drug-InducedGenetic Predisposition to DiseaseLevodopaAgedFemaleGenome-Wide Association StudyHumansMaleMiddle AgedParkinson DiseasePolymorphism, Single NucleotideProspective StudiesQuantitative Trait LociLevodopaGenetic determinantsIntegrative analysisInterventional targetsLevodopa induced dyskinesiaParkinson’s disease

Identifiers

PMID40299300
PMCPMC12367974

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.