Evidence map›Paper›PMID 40299289›Full record

ArticleDigestive diseases and sciences2025

Adipokine Profiles and Their Association with Body Composition and Disease Activity in Pediatric Crohn's Disease.

Ramit Magen-Rimon, Michal Cohen, Irit Rosen, Inna Spector-Cohen, Jamal Garah, Ram Weiss, Ron Shaoul

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Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ramit Magen-RimonFaculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel. ramit.magen@technion.ac.il.
Michal CohenFaculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
Irit RosenPediatric Gastroenterology & Nutrition Institute, Ruth Children's Hospital, Rambam Medical Center, Haifa, Israel.
Inna Spector-CohenFaculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
Jamal GarahPediatric Gastroenterology & Nutrition Institute, Ruth Children's Hospital, Rambam Medical Center, Haifa, Israel.
Ram WeissFaculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
Ron ShaoulFaculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesEmerging evidence implicates an important role for visceral fat, particularly "creeping fat," in the pathogeneses and progression of inflammatory bowel diseases (IBD), specifically Crohn's disease (CD). In this study, we aimed to explore the association between body composition, adipocytokine profiles, and disease activity in pediatric CD patients.

methodsWe recruited patients with active and quiescent CD, aged 6-18, along with age matched healthy controls. Body composition was analyzed via bio-impedance analysis, and adipocytokines were assessed by ELISA-multiplex.

resultsPatients with active CD exhibited significantly elevated levels of adiponectin and resistin compared to healthy controls and patients in remission even upon adjustment for body composition indices. Leptin correlated only with body composition and not with disease activity. Patients with active CD had relatively higher percentage of body fat and total body fat than the other groups.

conclusionsThis study underscores the complex interactions between adipocytokine profiles and disease activity in CD. Further studies are needed to investigate the potential mechanistic role of adiponectin and resistin in CD pathogenesis.

Indexed as

AdipokinesAdiponectinBody CompositionCrohn DiseaseResistinAdolescentCase-Control StudiesChildFemaleHumansLeptinMaleAdipokinesAdiponectinADIPOQ protein, humanLeptinResistinRETN protein, humanAdiponectinCrohn’s diseasePediatricResistin

Identifiers

PMID40299289
PMCPMC12367951

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