Evidence map›Paper›PMID 40299260›Full record

ArticleGeroScience2026

Associations of cardiorespiratory fitness with brain white matter microstructural integrity and white matter hyperintensity volume across the adult lifespan.

Junyeon Won, Takashi Tarumi, Tsubasa Tomoto, Kevin Shan, Karen M Rodrigue, Kristen M Kennedy, Denise C Park, Rong Zhang

Abstract read
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junyeon WonInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, 7232 Greenville Ave, Dallas, TX, 75231, USA.
Takashi TarumiInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, 7232 Greenville Ave, Dallas, TX, 75231, USA.
Tsubasa TomotoInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, 7232 Greenville Ave, Dallas, TX, 75231, USA.
Kevin ShanInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, 7232 Greenville Ave, Dallas, TX, 75231, USA.
Karen M RodrigueCenter for Vital Longevity, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA.
Kristen M KennedyCenter for Vital Longevity, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA.
Denise C ParkCenter for Vital Longevity, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA.
Rong ZhangInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, 7232 Greenville Ave, Dallas, TX, 75231, USA. RongZhang@TexasHealth.org.ORCID 0000-0002-6534-5216

Funding

Mild Cognitive Impairment: Cerebrovascular Dysfunction and Exercise TrainingR01AG033106 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG, ZHANG, RONG · 2009 to 2012
$3.1M
Arterial Aging, Brain Perfusion & Exercise: Impact on Brain Structure & Function.R01HL102457 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, RONG · 2010 to 2013
$2.1M
NHLBI NIH HHS R01HL102457NIA NIH HHS R01AG033106
6 · The paper itself

Abstract

Higher cardiorespiratory fitness (CRF) is associated with less deterioration in brain microstructural white matter (WM) integrity in older adults assessed with MRI diffusion tensor imaging (DTI) and brain WM hyperintensities (WMH) volume measured with fluid-attenuated-inversion-recovery (FLAIR) imaging. This study investigated associations of CRF measured with peak oxygen consumption (V̇O

Indexed as

AgingBrainCardiorespiratory FitnessWhite MatterAdultAgedCognitionDiffusion Tensor ImagingExercise TestFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOxygen ConsumptionAgingCardiorespiratory fitnessCognitive functionDiffusion-weighted MRIWhite matter hyperintensity

Identifiers

PMID40299260
PMCPMC12972398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.