ArticleMedical oncology (Northwood, London, England)2025
EZH2 inhibitor and Vismodegib synergistically inhibit the growth and metastasis of medulloblastoma.
Article in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Manganese-pyridone-catalyzed site-selective hydrogen isotope exchange of 2-arylpyridines using DRSC advances · 2026Article
- Vismodegib Exerts a Pleotropic Effect on Topotecan-Resistant and Sensitive Ovarian Cancer Cell Lines in 2D and 3D Cell Culture Models.Molecules (Basel, Switzerland) · 2026Article
- Medulloblastoma: Current Standard of Care and Future Treatment Opportunities.Paediatric drugs · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Resistance frequently arises when treating medulloblastoma (MB) patients with Vismodegib, markedly shortening their survival time. Consequently, the urgent problem to be solved is the discovery of a drug that can synergize with Vismodegib to improve its resistance in patients and enhance its efficacy. To validate the feasibility and efficacy of combining EZH2 (Enhancer of zeste homolog 2) inhibitor (EZH2i) with Vismodegib. A comprehensive assessment of their individual and combined effects on MB cell proliferation, migration, and invasion capabilities was conducted. The promising potential of EZH2i in inhibiting MB cell growth, migration and invasion was exhibited when used alone. Furthermore, when combined with Vismodegib, the inhibitory effect on MB was significantly potentiated. This synergy was further confirmed by SynergyFinder analysis, which revealed a remarkable highest single-agent score of 14.85 for the GSK126 and Vismodegib combination. Importantly, the enhanced efficacy of the combined EZH2i and Vismodegib therapy in suppressing tumor growth was also verified by the xenograft experiments in vivo. In summary, the combined use of EZH2i and Vismodegib demonstrated a remarkable synergistic effect in suppressing MB growth, presenting a promising treatment option for MB patients who had become resistant to Vismodegib.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.