ArticleAging clinical and experimental research2025
Causal effect between telomere length and thirteen types of cancer in Asian population: a bidirectional Mendelian randomization study.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe relationship between leukocyte telomere length (LTL) and the risk of developing various cancers has always been controversial and predominantly focused on European populations. Hence, Mendelian randomization (MR) was applied to the Asian population to explore the causal relationships between LTL and the risk of developing various cancers.
methodsWe explored the causal connection between LTL and the risk of developing thirteen types of cancer in Asian populations using freely available genetic variation data. The primary analytical method employed was the inverse variance weighted (IVW) method, complemented by sensitivity and validation analyses. Following Bonferroni correction, P < 0.0038 was considered to indicate statistical significance, and P values ranging from 0.0038 to 0.05 were considered to indicate a nominally significant association.
resultsThe findings indicated significant positive associations between LTL and the risk of developing lung cancer [odds ratio (OR) = 1.6009, 95% confidence interval (CI) 1.3056-1.9629, P = 6.08 × 10
conclusionsAsians with longer telomeres are more prone to developing lung and prostate cancer. There is also a nominally significant association between longer telomeres and the risk of developing hematological malignancy.
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