ArticleStem cell reviews and reports2025
G-CSF-Induced Emergency Granulopoiesis Modulates Neutrophil Effector Function in Mice.
Article in Stem cell reviews and reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Neutrophil extracellular traps formation driven by novel ELANE mutations in cyclic neutropenia patients.Genes and immunity · 2026Article
- SiglecF-expressing neutrophils differentiate from mature neutrophils locally in the heart after myocardial infarction.Experimental hematology · 2026Article
- Intraperitoneal G-CSF Stimulation Achieves Human-like Neutrophil Levels in NSG Mice Without Inducing Systemic Inflammation.International journal of molecular sciences · 2026Article
- TAK1 drives inflammatory fibroblast acquisition and shapes myocardial infarction responses in male mice.Nature communications · 2026Article
- Article
- Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer.Molecular oncology · 2026Review
- The neutrophil collective.Cell · 2025Review
- From disruption to remodeling: the evolution and therapeutic prospects of Neuroimmune Regulatory Circuitry after ischemic stroke.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Neutrophils function as first responders of the immune system by deploying cytotoxic armaments and orchestrating local inflammation. Their functionality is programmed during daily production in the bone marrow through granulopoiesis. During severe inflammation, increased neutrophil demand is met through activation of emergency granulopoiesis. The effect of emergency granulopoiesis on neutrophil functionality remains cryptic. In the present study, we assessed neutrophil function in mice injected with G-CSF (100 µg/kg/d for 3 days) to activate emergency granulopoiesis. We found that emergency granulopoiesis neutrophils exhibit impaired ROS production (n = 6, P = 0.003) and NETosis (n = 5, P < 0.01), but increase neutrophil elastase secretion (n = 9, P < 0.0001) and LPS-induced Tnfa, Il1b, Il1a, Il12a, and Ccl2 expression (n = 13, P < 0.01). To test the impact of emergency granulopoiesis neutrophils on the inflammatory response in vivo, we pre-treated mice with G-CSF and challenged them with zymosan to induce peritonitis. At 4 h post-zymosan injection, peritoneal neutrophils from G-CSF treated mice exhibit increased expression of Ccl2 (n = 3, P < 0.05). Subsequently, we observed enhanced peritoneal macrophage accumulation at 48 h post-zymosan administration in G-CSF-treated mice (n = 5, P < 0.05). These data indicate that emergency granulopoiesis programs neutrophils to have an enhanced immunomodulatory function that orchestrates the subsequent macrophage response in local tissue inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.