Evidence map›Paper›PMID 40299181›Full record

ArticleInternational urology and nephrology2025

Comparative efficacy of autologous adult live cultured buccal epithelial cells (AALBEC) and minced buccal mucosal graft endourethral urethroplasty (MBGEU) in male urethral stricture.

Kirti Singh, Abhay Singh Gaur, Swarnendu Mandal, Vivek Tarigopula, Manoj Kumar Das, Sambit Tripathy, C Sabique, Kalandi Barik, Prasant Nayak

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Kirti SinghUrology Department, AIIMS Bhubaneswar, Sijua, Patrapada, Bhubaneswar, Odisha, 751019, India.
Abhay Singh GaurDepartment of Urology, AIIMS Bhatinda, Bhatinda, Punjab, India.
Swarnendu MandalUrology Department, AIIMS Bhubaneswar, Sijua, Patrapada, Bhubaneswar, Odisha, 751019, India. urol_swarnendu@aiimsbhubaneswar.edu.in.
Vivek TarigopulaUrology Department, AIIMS Bhubaneswar, Sijua, Patrapada, Bhubaneswar, Odisha, 751019, India.
Manoj Kumar DasUrology Department, AIIMS Bhubaneswar, Sijua, Patrapada, Bhubaneswar, Odisha, 751019, India.
Sambit TripathyUrology Department, AIIMS Bhubaneswar, Sijua, Patrapada, Bhubaneswar, Odisha, 751019, India.
C SabiqueUrology Department, AIIMS Bhubaneswar, Sijua, Patrapada, Bhubaneswar, Odisha, 751019, India.
Kalandi BarikUrology Department, AIIMS Bhubaneswar, Sijua, Patrapada, Bhubaneswar, Odisha, 751019, India.
Prasant NayakUrology Department, AIIMS Bhubaneswar, Sijua, Patrapada, Bhubaneswar, Odisha, 751019, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo conduct a comparative analysis of autologous adult live cultured buccal epithelial cells (AALBEC) and minced buccal mucosal graft endourethral urethroplasty (MBGEU) in treatment of bulbar urethral stricture disease (USD) by evaluating and comparing their efficacy, safety, and patient outcomes.

methodsThis study was conducted in a tertiary-care center and included 90 males with primary, < 4 cm bulbar USD. In AALBEC arm (30 patients), AALBEC was implanted after DVIU. While in the MBGEU arm (60 patients), a 1 × 1 cm buccal mucosal graft was harvested, minced, centrifuged, and suspended in fibrin glue, and after DVIU, the suspension was instilled via a 5-Fr ureteric catheter over the urethrotomy site. The primary objective was to compare success rates. The secondary objectives were to compare changes in the American Urological Association (AUA) symptom score, peak flow rate (Qmax), and post-void residue (PVRU) post-operatively and also to look for any adverse events related to surgery.

resultsThe success rate of AALBEC was 73.33% and of MBGEU was 90% at 6 months (p 0.041). The stricture recurred in eight and six patients, respectively. Although both groups showed a significant increase in Qmax compared to preoperative values, MBGEU group demonstrated significantly greater improvement in Qmax at 3 months (p 0.002) and 6 months (p < 0.0001) compared to the AALBEC group. No significant donor site morbidity was seen. In AALBEC group, two patients had sepsis in postoperative period.

conclusionThe medium-term success of MBGEU is encouraging over AALBEC. However, a longer follow-up and further studies with a larger sample size are required.

Indexed as

Epithelial CellsMouth MucosaUrethraUrethral StrictureAdultAgedCells, CulturedHumansMaleMiddle AgedTransplantation, AutologousTreatment OutcomeUrologic Surgical Procedures, MaleAutologous adult live cultured buccal epithelial cells (AALBEC)Cystoscopic surgical proceduresCystoscopiesMale urethral strictureMinced buccal mucosal graft endourethral urethroplasty (MBGEU)Urethral stricture disease

Identifiers

PMID40299181

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