Evidence map›Paper›PMID 40299123›Full record

ArticleBulletin of experimental biology and medicine2025

Interferon α2b Selectively Modulates Ionotropic AMPA, but not NMDA Receptors of the Glutamatergic Synapse of the Vestibular Apparatus.

I V Ryzhova, E A Vershinina, T V Tobias

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

I V RyzhovaPavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. ireneryzhova@mail.ru.
E A VershininaPavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
T V TobiasPavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interferon (IFN) used in the treatment of severe viral infections and cancer can lead to acute hearing loss and balance problems. The effect of type I interferon IFNα2b on the function of the afferent glutamatergic synapse of the vestibular epithelium was studied in vitro using electrophysiological method and perfusion of the synaptic area with solutions containing glutamate (GLU) and ionotropic glutamate receptor agonists (AMPA, NMDA). IFNα2b selectively activates AMPA, but not NMDA receptors, and modulates the afferent flow from the sensory epithelium to CNS. The delayed activation of AMPA receptors is one of the mechanisms of the neuromodulatory effect of IFNα2b on glutamatergic synaptic transmission in the vestibular apparatus.

Indexed as

Interferon-alphaReceptors, AMPAReceptors, N-Methyl-D-AspartateSynapsesVestibule, LabyrinthAnimalsGlutamic AcidInterferon alpha-2MaleRatsSynaptic TransmissionGlutamic AcidInterferon-alphaInterferon alpha-2Receptors, AMPAReceptors, N-Methyl-D-Aspartateglutamateinterferonionotropic receptorsmodulationvestibular apparatus

Identifiers

PMID40299123

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.