ArticleBulletin of experimental biology and medicine2025
Telomere Length of Cardiomyocytes in Wistar Rat Treated with Doxorubicin: In Vivo Experimental Study.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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6 authors.
Funding
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Abstract
The effect of doxorubicin on the relative telomere length of cardiomyocytes in Wistar rats was studied. Doxorubicin (2 mg/kg body weight) was injected into the caudal vein once a week for 4 weeks, the control group was injected with 0.9% NaCl solution in an equivalent volume. The serum concentrations of proinflammatory cytokines (MCP-1 and TNFα), oxidative stress marker 8-hydroxydeoxyguanosine (8-OHdG), and telomerase reverse transcriptase (TERT) were measured. In rats treated with doxorubicin, the relative length of cardiomyocyte telomeres and serum levels of 8-OHdG were higher than the in control. Thus, molecular effects of subchronic low-dose doxorubicin exposure in rats were revealed: telomeric regions of cardiomyocyte DNA were lengthened, and the level of oxidative stress marker increased.
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