Evidence map›Paper›PMID 40299073›Full record

ReviewBrain structure & function2025

Due to difference in anatomical definitions, population variability and tractography methods, it will not be possible to standardize brain tractography for users, or will it?

Christian Beaulieu, Alessandro Daducci, Helen Mayberg, Alexander Leemans

Abstract readReview
PubMed Publisher
In one paragraph

Review in Brain structure & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christian BeaulieuDepartments of Radiology and Diagnostic Imaging & Biomedical Engineering, University of Alberta, 3-50D University Terrace, Edmonton, AB, T6G 2T4, Canada. christian.beaulieu@ualberta.ca.ORCID https://orcid.org/0000-0002-2342-3298
Alessandro DaducciDepartment of Computer Science, University of Verona, Verona, Italy.
Helen MaybergDepartment of Neurology, Neurosurgery, and Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.
Alexander LeemansImage Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands.

Funding

Electrophysiological Biomarkers to Optimize DBS for DepressionUH3NS103550 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MAYBERG, HELEN S, RIVA-POSSE, PATRICIO · 2017 to 2023
$7.7M
NIH HHS UH3NS103550
6 · The paper itself

Abstract

Standardization of diffusion MRI tractography remains a major challenge due to variability in anatomical definitions, subject-specific white matter organization, pathology, acquisition protocols, and tractography methods. This short communication summarizes the key points of a debate on the limitations and opportunities in standardizing tractography across basic research and clinical settings held at the 2024 Tract-Anat Retreat. While full harmonization may be infeasible, there is optimism given the high performance of many current tractography methods, their demonstrated utility in multiple applications, and flexibility for adapting to the previously mentioned variabilities. Ultimately, what will be best will depend on the brain region and application, thereby reflecting the need for multiple dedicated standardized protocols.

Indexed as

BrainDiffusion Tensor ImagingWhite MatterHumansImage Processing, Computer-AssistedBrainDiffusionMRIStandardizationTractography

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.