Evidence map›Paper›PMID 40299060›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025

Intracellular dark endothelial spots: A new imaging biomarker for the development of bullous keratopathy after cataract surgery.

Taiyo Shijo, Yukari Yagi-Yaguchi, Osama Ibrahim, Hirotsugu Kasamatsu, Yurina Mori-Ogiwara, Daisuke Tomida, Hisashi Noma, Dogru Murat, Takefumi Yamaguchi

Abstract read
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Taiyo ShijoDepartment of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, 5 - 11 - 13, Sugano, Ichikawa, Chiba, 272 - 8513, Japan.
Yukari Yagi-YaguchiDepartment of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, 5 - 11 - 13, Sugano, Ichikawa, Chiba, 272 - 8513, Japan.
Osama IbrahimDepartment of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, 5 - 11 - 13, Sugano, Ichikawa, Chiba, 272 - 8513, Japan.
Hirotsugu KasamatsuDepartment of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, 5 - 11 - 13, Sugano, Ichikawa, Chiba, 272 - 8513, Japan.
Yurina Mori-OgiwaraDepartment of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, 5 - 11 - 13, Sugano, Ichikawa, Chiba, 272 - 8513, Japan.
Daisuke TomidaDepartment of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, 5 - 11 - 13, Sugano, Ichikawa, Chiba, 272 - 8513, Japan.
Hisashi NomaDepartment of Data Science, The Institute of Statistical Mathematics, Tokyo, Japan.
Dogru MuratDepartment of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, 5 - 11 - 13, Sugano, Ichikawa, Chiba, 272 - 8513, Japan.
Takefumi YamaguchiDepartment of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, 5 - 11 - 13, Sugano, Ichikawa, Chiba, 272 - 8513, Japan. yamaguchit@tdc.ac.jp.ORCID http://orcid.org/0000-0002-2546-2813

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIntracellular dark endothelial spots (IDES) on specular microscopy indicate corneal endothelial stress, and can be an imaging biomarker for subsequent endothelial cell density (ECD) loss after endothelial keratoplasty. This study evaluated the risk factors for the development of bullous keratopathy (BK) by comparing low ECD patients with or without IDES before cataract surgery.

methodsThis retrospective study included 106 consecutive patients who underwent cataract surgery with a preoperative ECD of less than 1000 cells/mm

resultsThe mean preoperative ECD was 687 ± 124 cells/mm

conclusionIDES can be used as a new imaging biomarker that suggests a potential risk for development of BK in patients with shallow anterior chamber who are to undergo cataract surgery.

Indexed as

Cataract ExtractionCorneal DiseasesEndothelium, CornealPostoperative ComplicationsAgedAged, 80 and overBiomarkersCell CountCorneal Endothelial Cell LossFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesRisk FactorsBiomarkersBullous keratopathyCataract surgeryEndothelial cell densityIntracellular dark endothelial spotSpecular microscopy

Identifiers

PMID40299060

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.