ArticleEuropean journal of applied physiology2025
Impact of menopause on responses to hypoxia and incidence of acute mountain sickness.
Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeMenopause results in decreased ovarian hormones, potentially impacting physiological responses to hypoxia and its tolerance. This study explored menopause's influence on physiological responses during rest and exercise in normobaric hypoxia and its role in predicting acute mountain sickness (AMS).
methodsThirteen eumenorrheic women in their mid-luteal phase (EW, age = 32 ± 8 year) and fifteen postmenopausal women (PW, age = 63 ± 2 year) were examined on two occasions. Their ovarian hormonal levels were measured. In the first visit, hypoxic ventilatory response (HVR), physiological responses (ventilation, pulse oximetry, and heart rate) at rest and exercise in normobaric hypoxia (F
resultsPW exhibited lower estradiol (16.9 ± 16.7 vs 4.6 ± 2.3 pg/ml, p < 0.01) and progesterone (13.39 ± 7.61 vs 0.06 ± 0.07 ng/ml, p < 0.001) levels than EW. Despite higher ventilation at rest in EW compared to PW in normoxia (10.0 ± 1.5 vs 8.5 ± 0.9 L/min; p < 0.01) and hypoxia (9.4 ± 1.3 vs 8.2 ± 1.3 L/min) , HVR (- 0.34 ± 0.13 vs - 0.27 ± 0.15 L/min/%) was similar between groups (p = 0.26). AMS incidence did not differ between EW (31%) and PW (40%).
conclusionIn conclusion, EW had higher ventilation at rest in normoxia and normobaric hypoxia compared to PW, but similar responses and AMS incidence at high altitude. Age has minimal impact on HVR in women.
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