ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025
Loosening of stand-alone ALIF versus TLIF in degenerated lumbar human spines: an in vitro biomechanical study.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Risk factors for pedicle screw loosening: a comprehensive review.Journal of orthopaedic surgery and research · 2025Review
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11 authors.
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Abstract
purposeBiomechanical investigation is needed to determine whether stand-alone anterior lumbar interbody fusion with integrated screws (ALIF) is advisable for use in elderly patients. This study aimed to test three null hypotheses: (1) cyclic loading does not cause loosening of ALIF in degenerated lumbar specimens, (2) cyclic loading does not cause loosening in transforaminal lumbar interbody fusion (TLIF) in degenerated lumbar specimens, and (3) Neutral Zone (NZ) and Range of motion (ROM) of ALIF and TLIF do not differ after cyclic loading.
methodsTwelve fresh-frozen human cadaveric lumbar motion segments (L1-5, donors' age 76.1 ± 6.7 years; trabecular BMD 97.1 ± 36.9 mgHA/cm
resultsCyclic loading significantly increased NZ of ALIF specimens in Flex-Ext (1.69 ± 1.81°, p =.048) and LB (1.84 ± 1.81°, p =.036), and showed a trend to significance in AR (0.46 ± 0.54°, p =.065). NZ of TLIF specimens did not increase significantly in any motion direction (p ≥.112). ROM and NZ did not differ significantly between ALIF and TLIF in post-cyclic states(p ≥.556).
conclusionAxial compression loading caused significant loosening of ALIF in Flex-Ext and LB, but not of TLIF in degenerated lumbar human cadaveric specimens. Hence, standalone ALIF cannot be recommended without reservation for the use in elderly patients with degenerative lumbar spines. However, the absolute differences between pre- and post-cyclic states were small, and ROM and NZ of ALIF after cyclic loading were comparable to TLIF.
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