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ArticleInternational urogynecology journal2025

Association of the Triglyceride Glucose Index with Symptoms of Overactive Bladder in American Female Adults: A Cross-Sectional Study.

Ke Huang, Shan Yin, Jianwei Cui, Jiahao Wang, Jia Wang, Yunjin Bai

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Article in International urogynecology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Ke Huang *Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
Shan Yin *Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Jianwei Cui *Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
Jiahao WangDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
Jia WangDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. wangjiawch@163.com.
Yunjin BaiDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. baiyunjin@163.com.

Funding

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6 · The paper itself

Abstract

introduction and hypothesisTo investigate the potential correlation between the triglyceride-glucose (TyG) index and overactive bladder (OAB) symptoms within the female population.

methodsThis study used data from 7941 individuals obtained from the National Health and Nutrition Examination Survey (NHANES) 2005-2018 dataset. The following equation is used to calculate the TyG index: TyG = Ln [fasting triglycerides (mg/dL) * fasting glucose (mg/dL)/2]. The symptoms of OAB were based on individuals' self-reported comprehensive score. Weighted logistic regression models, encompassing both univariable and multivariable analyses, were employed to evaluate the relationship between the TyG index and OAB in women.

resultsAfter conducting extensive modifications, the multivariable logistic regression model revealed a significant correlation between the TyG index and mild OAB among American female adults (OR 1.36, 95% CI 1.09-1.70, P = 0.006). Upon categorizing the TyG index into 4 grades (Q1-Q4), a positive increase in OR values corresponding to higher TyG index grades can be observed.

conclusionsIn this study, our findings reveal a significantly positive relationship between elevated TyG index values and an increased prevalence of mild OAB among female adults. These findings suggest that metabolic dysregulation may drive early-stage OAB, while severe OAB symptoms may be more dependent on non-metabolic pathological changes. Further investigation is warranted to elucidate the underlying mechanisms in female adults.

Indexed as

Blood GlucoseTriglyceridesUrinary Bladder, OveractiveAdultAgedCross-Sectional StudiesFemaleHumansMiddle AgedNutrition SurveysPrevalenceUnited StatesBlood GlucoseTriglyceridesFemaleInsulin resistanceNHANESOveractive bladderTriglyceride-glucose index

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.