Evidence map›Paper›PMID 40298954›Full record

ArticleInternational orthopaedics2025

Alterations in coagulation profile of patients with periprosthetic joint infections.

Augusto Carlos Maciel Saraiva, Alan de Paula Mozella, Hugo Alexandre de Araujo Barros Cobra, Osamu de Sandes Kimura, João Antonio Matheus Guimarães, Helton Defino, Ana Carolina Leal

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Article in International orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Augusto Carlos Maciel SaraivaOrthopaedic Department, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-6408-3245
Alan de Paula MozellaCenter for Surgery of Knee, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-5855-5808
Hugo Alexandre de Araujo Barros CobraCenter for Surgery of Knee, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-7315-0961
Osamu de Sandes KimuraCenter for Surgery of Hip, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-6350-6709
João Antonio Matheus GuimarãesTeaching and Research Division, National Institute of Traumatology and Orthopaedics, Avenida Brasil, 500, Rio de Janeiro, RJ, 20940-070, Brasil.ORCID http://orcid.org/0000-0002-4088-044X
Helton DefinoDepartment of Orthopaedics and Anaesthesiology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-4274-0130
Ana Carolina LealTeaching and Research Division, National Institute of Traumatology and Orthopaedics, Avenida Brasil, 500, Rio de Janeiro, RJ, 20940-070, Brasil. leal.carol@gmail.com.ORCID http://orcid.org/0000-0002-2556-3446

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to evaluate changes in the coagulation profile of patients with knee periprosthetic infections (PJI) and determine its diagnostic value in this complication.

methodsA prospective study was conducted with 112 patients who underwent revision surgery for total knee arthroplasty in a single tertiary hospital between January 2021 and December 2022.

results51 patients were diagnosed with PJI. D-dimer (p = 0.001), fibrinogen (p = 0.0007), platelets (0.01), and international normalized ratio (p = 0.01) were significantly higher in patients with PJI.

conclusionsPatients with PJI display altered coagulation profile. The evaluation of coagulation-related markers has limited value for diagnosing PJI. Further studies are needed to understand the impact of such alterations on patients' outcomes.

Indexed as

Arthroplasty, Replacement, KneeBlood CoagulationKnee ProsthesisProsthesis-Related InfectionsAgedAged, 80 and overBiomarkersFemaleFibrin Fibrinogen Degradation ProductsFibrinogenHumansInternational Normalized RatioMaleMiddle AgedProspective StudiesReoperationBiomarkersFibrin Fibrinogen Degradation Productsfibrin fragment DFibrinogenBiomarkerCoagulationHaemostasisPeriprosthetic joint infection

Identifiers

PMID40298954
PMCPMC12179001

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