Evidence map›Paper›PMID 40298815›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Involvement of Nuclear Receptors PPAR-α, PPAR-γ, and the Transcription Factor Nrf2 in Cellular Protection Against Oxidative Stress Regulated by H

Luz Ibarra-Lara, Araceli Sánchez-López, Leonardo Del Valle-Mondragon, Elizabeth Soria-Castro, Gabriela Zarco-Olvera, Mariana Patlán, Verónica Guarner-Lans, Juan Carlos Torres-Narváez, Angélica Ruiz-Ramírez, Fernando Díaz de León-Sánchez and 2 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. HBiomedicines · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Luz Ibarra-LaraDepartment of Pharmacology, National Institute of Cardiology Ignacio Chávez, Mexico City 14080, Mexico.
Araceli Sánchez-LópezDepartment of Pharmacobiology, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City 07360, Mexico.
Leonardo Del Valle-MondragonDepartment of Pharmacology, National Institute of Cardiology Ignacio Chávez, Mexico City 14080, Mexico.ORCID 0000-0002-2999-1050
Elizabeth Soria-CastroDepartment of Cardiovascular Biomedicine, National Institute of Cardiology Ignacio Chavez, Mexico City 14080, Mexico.ORCID 0000-0001-8050-1961
Gabriela Zarco-OlveraDepartment of Pharmacology, National Institute of Cardiology Ignacio Chávez, Mexico City 14080, Mexico.
Mariana PatlánSubdirectorate of Basic and Technological Research, National Institute of Cardiology Ignacio Chávez, Mexico City 14080, Mexico.
Verónica Guarner-LansDepartment of Physiology, National Institute of Cardiology Ignacio Chavez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico.
Juan Carlos Torres-NarváezDepartment of Pharmacology, National Institute of Cardiology Ignacio Chávez, Mexico City 14080, Mexico.
Angélica Ruiz-RamírezDepartment of Cardiovascular Biomedicine, National Institute of Cardiology Ignacio Chavez, Mexico City 14080, Mexico.
Fernando Díaz de León-SánchezLaboratory of Post-harvest of Plant Genetic Resources and Natural Products, Department of Health Sciences, Autonomous Metropolitan University, Iztapalapa Campus, Mexico City 09310, Mexico.ORCID 0000-0001-7176-2457
Víctor Hugo Oidor-ChanDepartment of Biotechnology, Autonomous Metropolitan University, Iztapalapa Campus, Av. Ferrocarril San Rafael Atlixco 186, Leyes de Reforma, Iztapalapa, Mexico City 09310, Mexico.ORCID 0000-0002-8910-5671
Vicente Castrejón-TéllezDepartment of Physiology, National Institute of Cardiology Ignacio Chavez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico.ORCID 0000-0002-8518-6961

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial oxidative stress increases under conditions of hyperglycemia and ischemia/reperfusion (I/R) injury, leading to cellular damage. Inhibition of oxidative stress is involved in the cardioprotective effects of hydrogen sulfide (H

Indexed as

antioxidant capacityhyperglycemiahypoxia–reoxygenationPPAR-αPPAR-γsodium hydrosulfide (NaHS)

Identifiers

PMID40298815
PMCPMC12024258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.