ReviewAntioxidants (Basel, Switzerland)2025
Major Oxidative and Antioxidant Mechanisms During Heat Stress-Induced Oxidative Stress in Chickens.
Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Dietary Echinacea purpurea Attenuates Oxidative Stress and Alters Cytokine Gene Expression Among Heat-Stressed Broiler Chickens at High Altitude.Veterinary medicine and science · 2026Article
- Probiotics as a Strategy for Mitigating Viral Infections in Poultry: Immunomodulatory Mechanisms and Therapeutic Potential.Veterinary medicine and science · 2026Review
- Identifying adaptive variation in spatially structured populations using low-coverage whole-genome sequencing data.Molecular biology and evolution · 2026Article
- The Effects of Chicory Aqueous Extract on Antioxidant Capacity, Immune Response, and Intestinal Function in Broilers.Animals : an open access journal from MDPI · 2026Article
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- Article
- Effects of 1-Deoxynojirimycin-Enriched Mulberry Extract on Liver and Gut Health in Broilers Under a High-Fat Diet.Animals : an open access journal from MDPI · 2026Article
- Acute Thermal Elevation Alters Cellular Metabolic Activity, Redox Balance, and Iron Homeostasis in Butterfly Lizards (Animals : an open access journal from MDPI · 2026Article
- Effects of dietary threonine and arginine on growth performance, stress indicators, and gut health in broiler chickens under multiple stress.Journal of animal science and technology · 2026Article
- Dose-response evaluation of feed additive tert-butylhydroquinone on performance, hepatic antioxidant, gut health, and functional microbiome in heat-stressed broiler chickens.Poultry science · 2026Article
- Impact of Huoxiang Zhengqi oral liquid on the performance, egg quality, antioxidant capacity via reshaping gut microbiota in laying hens under acute heat stress.Poultry science · 2026Article
- Dietary Chlorogenic Acid Attenuates Liver Injury, Lipid Metabolic Disturbance, and Inflammatory Responses in Broilers Under High Stocking Density.Animals : an open access journal from MDPI · 2026Article
- Nutritional Modulation of Epigenetic Responses to Heat Stress in Farm Animals: Evidence, Limitations and Perspectives.Animals : an open access journal from MDPI · 2026Review
- Protein Disulfide Isomerase A6 (PDIA6) Restrains Heat-Induced Oxidative Damage in Haemocytes of the Pacific Oyster (Antioxidants (Basel, Switzerland) · 2026Article
- Dietary supplementation with natto fermented by Bacillus subtilis var. natto strain TTCC903 alleviates heat stress and improves egg production in aged laying hens.Poultry science · 2026Article
- Host-derived Limosilactobacillus reuteri R30 and Cytobacillus solani Y5 improve growth performance and intestinal health of Danzhou chickens by regulating the jejunal microbiota.Poultry science · 2026Article
- Effects of Dietary DL-Methionine Supplementation on Meat Quality and Antioxidant Capacity in Wenchang Chickens Subjected to Chronic Heat Stress.Animals : an open access journal from MDPI · 2026Article
- L-cysteine enhances heat-stress adaptation in meat-type chickens through modulation of cysteine-metabolic and nutrient transporter genes.Poultry science · 2026Article
- The role of cyclooxygenase-2 in oxidative stress and inflammation: Implications for poultry health and production.Poultry science · 2026Review
- Dietary heat-killedVeterinary and animal science · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress (HS) is one of the most important stressors in chickens, and its adverse effects are primarily caused by disturbing the redox homeostasis. An increase in electron leakage from the mitochondrial electron transport chain is the major source of free radical production under HS, which triggers other enzymatic systems to generate more radicals. As a defense mechanism, cells have enzymatic and non-enzymatic antioxidant systems that work cooperatively against free radicals. The generation of free radicals, particularly the reactive oxygen species (ROS) and reactive nitrogen species (RNS), under HS condition outweighs the cellular antioxidant capacity, resulting in oxidative damage to macromolecules, including lipids, carbohydrates, proteins, and DNA. Understanding these detrimental oxidative processes and protective defense mechanisms is important in developing mitigation strategies against HS. This review summarizes the current understanding of major oxidative and antioxidant systems and their molecular mechanisms in generating or neutralizing the ROS/RNS. Importantly, this review explores the potential mechanisms that lead to the development of oxidative stress in heat-stressed chickens, highlighting their unique behavioral and physiological responses against thermal stress. Further, we summarize the major findings associated with these oxidative and antioxidant mechanisms in chickens.
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