Evidence map›Paper›PMID 40298810›Full record

ReviewAntioxidants (Basel, Switzerland)2025

Unveiling the Impacts of Cashew Nuts on Oxidative Stress in Rats: A Systematic Review.

Roque Ribeiro da Silva Júnior, Vinicius Ilei Oliveira Rodrigues, Camila Fernandes Maia de Carvalho, Márcio Matheus Barros Moura, Deymisson Damitene Martins Feitosa, Emanuel Kennedy Feitosa Lima, Ariel Moraes de Andrade, Joel Freires de Alencar Arrais, Larissa Nayara de Souza, Maria Irany Knackfuss and 6 more

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Epigenetic Mechanisms Involved in Hcv Infection and Human HCC.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Roque Ribeiro da Silva JúniorPostgraduate Program in Health and Society, State University of Rio Grande do Norte, Mossoró 59607-360, Brazil.ORCID 0000-0001-9517-6823
Vinicius Ilei Oliveira RodriguesPostgraduate Program in Health and Society, State University of Rio Grande do Norte, Mossoró 59607-360, Brazil.
Camila Fernandes Maia de CarvalhoPostgraduate Program in Health and Society, State University of Rio Grande do Norte, Mossoró 59607-360, Brazil.
Márcio Matheus Barros MouraDepartment of Veterinary Medicine, Federal Rural University of Semi-Arid, Mossoró 59625-900, Brazil.
Deymisson Damitene Martins FeitosaMulticenter Postgraduate Program in Biochemistry and Molecular Biology (PMBqBM), Rio Grande do Norte State University, Mossoró 59607-360, Brazil.ORCID 0009-0008-4542-5922
Emanuel Kennedy Feitosa LimaMulticenter Postgraduate Program in Biochemistry and Molecular Biology (PMBqBM), Rio Grande do Norte State University, Mossoró 59607-360, Brazil.ORCID 0000-0001-6141-140X
Ariel Moraes de AndradePostgraduate Program in Health and Society, State University of Rio Grande do Norte, Mossoró 59607-360, Brazil.
Joel Freires de Alencar ArraisPostgraduate Program in Health and Society, State University of Rio Grande do Norte, Mossoró 59607-360, Brazil.
Larissa Nayara de SouzaPostgraduate Program in Health and Society, State University of Rio Grande do Norte, Mossoró 59607-360, Brazil.
Maria Irany KnackfussPostgraduate Program in Health and Society, State University of Rio Grande do Norte, Mossoró 59607-360, Brazil.
José Rodolfo Lopes de Paiva CavalcantiPostgraduate Program in Health and Society, State University of Rio Grande do Norte, Mossoró 59607-360, Brazil.ORCID 0000-0002-1554-3249
Thales Allyrio Araújo De Medeiros FernandesPostgraduate Program in Health and Society, State University of Rio Grande do Norte, Mossoró 59607-360, Brazil.ORCID 0000-0003-4559-8918
Marcos Antônio Pereira Dos SantosDepartment of Physical Education, Federal University of Piauí, Teresina 64049-550, Brazil.ORCID 0000-0002-0755-6138
Ivana Alice Teixeira FonsecaPostgraduate Program in Health and Society, State University of Rio Grande do Norte, Mossoró 59607-360, Brazil.
Adalberto Veronese da CostaPostgraduate Program in Health and Society, State University of Rio Grande do Norte, Mossoró 59607-360, Brazil.ORCID 0000-0001-6597-463X
Glêbia Alexa CardosoPostgraduate Program in Health and Society, State University of Rio Grande do Norte, Mossoró 59607-360, Brazil.ORCID 0000-0003-4822-1673

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 11111
6 · The paper itself

Abstract

introductionThe fruit of the cashew tree, known as cashew, is accompanied by the fleshy extension of its stem, referred to as the cashew nut. Rich in phenolic compounds, such as phenolic acids, anthocyanins, flavonoids, carotenoids, polyphenols, as well as vitamins C and E, the cashew nut exhibits antioxidant properties.

objectiveThis systematic review investigated the effects of cashew nuts on oxidative stress in rats. METHODOLOGY: The study followed PRISMA guidelines and was registered in PROSPERO. Searches were conducted in the Medline (PubMed), EMBASE, BVS, MedRxiv, Science Direct, Scopus, and Web of Science databases. Experimental studies with rats as the target population, evaluating the effects of cashew nut supplementation on oxidative stress, antioxidant enzymatic activities, and inflammatory markers, were included. Exclusion criteria comprised dissertations, reviews, expert opinions, duplicates, and preprints.

resultsFive studies published between 2018 and 2022 were included, all utilizing cashew nut supplementation as the intervention. The results demonstrated a significant reduction in oxidative stress, an increase in the activity of antioxidant enzymes, such as SOD and catalase, and a decrease in inflammatory markers, including TNF-α and IL-1β. The most effective dose was 100 mg/kg/day, yielding consistent results across studies.

conclusionCashew nuts show potential for reducing oxidative stress, mitigating inflammation, and enhancing antioxidant defenses in rats. However, further clinical studies are required to better explore their benefits in humans, a field that remains less studied compared to other types of nuts.

Indexed as

Anacardiumantioxidantoxidative stressratsreactive oxygen speciesredox balance

Identifiers

PMID40298810
PMCPMC12024215

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.