ReviewAntioxidants (Basel, Switzerland)2025
Oxidation-Induced Mixed Disulfide and Cataract Formation: A Review.
Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Lens tissue transcriptome analysis in patients with total congenital cataract.Human genomics · 2026Article
- Review
- Revealing the therapeutic potential of Laminaria japonica polysaccharides against cataract: evidence from transcriptomics, network pharmacology, and in vivo experiments.International ophthalmology · 2026Article
- Lens aging and disease: Molecular mechanisms, functional consequences, and pharmacological implications.Progress in retinal and eye research · 2026Review
- Combating posterior capsular opacification: From conventional intraocular lens modifications to proactive defense via interface engineering.Materials today. Bio · 2026Review
- Retinal pigment epithelium pathology in age-related macular degeneration: mitigation with melatonin.Frontiers in medicine · 2026Review
- Retinoprotective Effects of Abscisic Acid in Ischemic Retinopathy Mouse Model.Antioxidants (Basel, Switzerland) · 2025Article
- Selenium Nanoparticles: Synthesis, Stability and In Vitro Evaluation in Human Lens Epithelial Cells.Pharmaceutics · 2025Article
- From Pathophysiology to Innovative Therapies in Eye Diseases: A Brief Overview.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The major function of eye lens is to transmit light onto retina and form an image. This relies on the crystallin proteins, which are tightly packed to achieve a high refractive index and transparency. The proteins are protected and maintained in a reduced state with intrinsic antioxidants, such as glutathione (GSH), and redox-regulating enzyme systems, such as thioltransferase to maintain the SH/-S-S-balance. When the protective systems are impaired or reduced due to aging, oxidative stress can lead to SH/S-S imbalance, protein modification, protein-protein aggregation and loss of transparency (cataract). Oxidative stress is considered the major culprit in senile cataract formation since cataractous lenses are typically low in GSH content and have elevated levels of GS-protein mixed disulfide (PSSG). This review will examine PSSG accumulation with age and cataracts and explore the possible role of oxidants such as H
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.