ReviewAntioxidants (Basel, Switzerland)2025
Natural Compounds with Beneficial Effects on Skin Collagen Type I and Mechanisms of Their Action.
Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Article
- Article
- Nicotinamide Improves Skin Photoaging in Mice by Delaying Cellular Senescence and Suppressing the Senescence-Associated Secretory Phenotype.Current issues in molecular biology · 2026Article
- Evaluation ofMedical sciences (Basel, Switzerland) · 2026Article
- Mandelamide Isolated fromBiomolecules · 2026Article
- Preparation of Uniform PEG-PLLA Microspheres via Membrane Emulsification for Soft Tissue Filling Applications.Journal of functional biomaterials · 2026Article
- Phytochemical profiling of Rosmarinus officinalis aerial parts and exploring its in vitro wound healing activity and network pharmacology.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The skin, as the largest external organ, is exposed to many environmental factors, such as sunlight and pollution, as well as some synthetic ingredients in cosmetic products used in excess by most people of all ages throughout their lives. Under the influence of these factors and with age, the amount of the key building protein, collagen type I, decreases, which leads to a deterioration in the appearance and condition of the skin. Currently, when the average life expectancy increases, the esthetic aspect and maintaining healthy skin are particularly important. In the cosmetic and pharmaceutical industries, attempts have long been made to prevent skin aging by the application of products containing natural compounds, mainly due to their high antioxidant activity. This review collects natural compounds, mainly polyphenols, with stimulating and protective effects on collagen type I in human skin fibroblasts, along with a description of the mechanisms of their action. Some of them have been tested on mice and rats, as well as in clinical trials, and in most cases, the results have been very promising. Nevertheless, there is still a need for an intensification of clinical studies in order to determine their appropriate dosage, safety, and effectiveness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.