ReviewAntioxidants (Basel, Switzerland)2025
Unexplored Mechanisms of Photoprotection: Synergistic Light Absorption and Antioxidant Activity of Melanin.
Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Microbial pigments as multi-functional cosmeceuticals: mechanism of action and sustainable production.Archives of microbiology · 2026Review
- Pigmented fungi derived from hot and cold deserts ecosystems: taxonomy, genomic and biotechnological approach.World journal of microbiology & biotechnology · 2026Review
- Allomelanin: A Promising Alternative to Polydopamine for Bioapplications.Journal of functional biomaterials · 2026Review
- The DiatomAntioxidants (Basel, Switzerland) · 2025Article
- Melanin-Related Materials in Electrochemical Sensors for Monitoring the Environment and Food.Biosensors · 2025Review
- Photothermal Release by Melanin-like Nanoparticles: Biomedical Applications.Journal of functional biomaterials · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light exposure has relevant effects both on living organisms and artificial materials. In particular, ultraviolet radiation is known to kill living cells and damage human skin but also degrade important artificial materials like plastics. In nature, the main pigment responsible for photoprotection is melanin, which is able both to prevent penetration of light by absorption and scattering and to block the action of light-generated radicals thanks to its antioxidant properties. The combination of light extinction with antioxidant action is still the most diffused and effective approach to photoprotection. Nevertheless, up to now, these two mechanisms, light extinction and antioxidant activity, have been considered independent. Recent studies showed that exposing melanin to light leads to an increase in its radical content and possibly in its antioxidant activity. Do light extinction and antioxidant activity work in synergy for photoprotection in nature? In this paper, we discuss the steps still needed to answer this intriguing question.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.