Evidence map›Paper›PMID 40298539›Full record

ArticleAntibiotics (Basel, Switzerland)2025

Structure-Activity Study of the Antimicrobial Lipopeptide Humimycin A and Screening Against Multidrug-Resistant

Md Ramim Tanver Rahman, Louis-David Guay, Ismail Fliss, Eric Biron

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Antibiotics (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Md Ramim Tanver RahmanFaculty of Pharmacy, Université Laval, Québec, QC G1V 0A6, Canada.ORCID 0000-0003-0689-7173
Louis-David GuayFaculty of Pharmacy, Université Laval, Québec, QC G1V 0A6, Canada.ORCID 0000-0001-8328-7550
Ismail FlissInstitute of Nutrition and Functional Foods, Université Laval, Québec, QC G1V 0A6, Canada.
Eric BironFaculty of Pharmacy, Université Laval, Québec, QC G1V 0A6, Canada.ORCID 0000-0002-8030-6741

Funding

Fonds de recherche du Québec-Nature et Technologie (FRQNT) Grant #2022-PR-191869
6 · The paper itself

Abstract

backgroundThe emergence of multidrug-resistant (MDR)

objectivesThe aim of this study is to explore the structure-function relationship of the lipopeptide humimycin A, compare the spectrum of activity of the synthetic analogs against a panel of

methodsHumimycin A and 15 analogs were produced by solid-phase peptide synthesis, and their antimicrobial activity was evaluated by agar diffusion and microtitration assays against 19

resultsAmong the synthesized peptides, four humimycin analogs exhibited activity against methicillin-sensitive and methicillin-resistant

conclusionsThe findings underscore the potential of humimycin analogs as antimicrobials for preventing and treating MDR

Indexed as

alternative to antibioticsantibiotic resistanceantimicrobialsbovine mastitischemical synthesishumimycinlipopeptidesmultidrug-resistant Staphylococcus aureus

Identifiers

PMID40298539
PMCPMC12024397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.