SynthesisLiver international : official journal of the International Association for the Study of the Liver2025
Donor-Related Risk Factors for Normothermic Machine Perfusion in Liver Transplantation: A Meta-Analysis.
Synthesis in Liver international : official journal of the International Association for the Study of the Liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Normothermic Perfusion Versus Static Cold Storage in Liver Transplantation: A Meta-Analysis of Randomized Trials.Clinical transplantation · 2025Pooled it
- Re-Evaluating Donor-Recipient Risk Scores in the Machine Perfusion Era Using a Large Multicenter Cohort: Do Traditional Predictive Models Still Apply?Clinical transplantation · 2026Article
- Focal Hepatic Hypoperfusion After Normothermic Machine Perfusion of Liver Grafts Is Associated with a Higher Comprehensive Complication Index.Bioengineering (Basel, Switzerland) · 2026Article
- Machine Perfusion Across Marginal Liver Grafts: Benefits and Challenges.Journal of personalized medicine · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsDuring normothermic machine perfusion (NMP), a variety of criteria are used to gauge the suitability of an organ for transplantation. However, the relations between donor factors and these criteria are poorly understood. The aim of this meta-analysis was to investigate the association between donor-related risk factors and the decision to transplant a liver subjected to NMP.
methodsA comprehensive literature search was performed for articles published up to March 2025 in four databases, reporting livers subjected to NMP for viability assessment prior to transplantation. Effect size (ES) was calculated using Cohen's D and log odds ratio.
resultsOut of 806 unique articles, 18 were included in this meta-analysis, encompassing 690 liver grafts that underwent NMP. Following viability assessment during NMP, utilisation rate was 82% from donors after brain death and 68% from donors after circulatory death (ES: 0.08, p = 0.88). Transplanted livers had shorter cold ischemia time (ES: -0.34, p = 0.003) and lower liver weight (ES: -0.53, p < 0.001). Donor age, BMI and donor warm ischemia time did not differentiate between transplanted and unused groups. Differences were observed in viability assessment for lactate clearance (ES: 2.0, p = 0.005), glucose metabolism (ES: 2.2, p < 0.001), bile production (ES: 1.0, p = 0.003) and pH (ES: 1.9, p < 0.001). Excellent outcomes, including 10% non-anastomotic strictures, 89% graft survival and 93% patient survival, were achieved in a large cohort of high-risk livers.
conclusionCold ischemia time and liver weight were identified as donor-related risk factors, whereas donor type, age and donor warm ischemia time appear not to impact the decision to transplant during NMP.
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