Evidence map›Paper›PMID 40298394›Full record

ArticlemSystems2025

Biophysical modeling reveals the transcriptional regulatory mechanism of Spo0A, the master regulator in starving

Yujia Zhang, Cristina S D Palma, Zhuo Chen, Brenda Zarazúa-Osorio, Masaya Fujita, Oleg A Igoshin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Metabolic Engineering Strategy forFoods (Basel, Switzerland) · 2025
    Review
  3. Rewilding microbiology.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yujia ZhangDepartment of Bioengineering, Rice University, Houston, Texas, USA.ORCID 0000-0003-4297-1641
Cristina S D PalmaDepartment of Bioengineering, Rice University, Houston, Texas, USA.ORCID 0000-0002-0390-1440
Zhuo ChenDepartment of Bioengineering, Rice University, Houston, Texas, USA.
Brenda Zarazúa-OsorioDepartment of Biology and Biochemistry, University of Houston, Houston, Texas, USA.
Masaya FujitaDepartment of Biology and Biochemistry, University of Houston, Houston, Texas, USA.
Oleg A IgoshinDepartment of Bioengineering, Rice University, Houston, Texas, USA.ORCID 0000-0002-1449-4772

Funding

Jenny and Antti Wihuri FoundationNational Science Foundation MCB-2204402Welch Foundation C-1995, E-2099-20220331
6 · The paper itself

Abstract

In starving IMPORTANCE: Cell differentiation is often critical for survival. In bacteria, differentiation decisions are controlled by transcriptional master regulators under transcriptional feedback control. Therefore, understanding how master regulators are transcriptionally regulated is required to understand differentiation. However, in many cases, the underlying regulation is complex, with multiple transcription factor binding sites and multiple promoters, making it challenging to dissect the exact mechanisms. Here, we address this problem for the

Indexed as

Bacillus subtilisBacterial ProteinsGene Expression Regulation, BacterialTranscription FactorsTranscription, GeneticBinding SitesPromoter Regions, GeneticBacterial ProteinsSpo0A protein, Bacillus subtilisTranscription Factors0A boxesBacillus subtilisbiophysical modelspo0A transcriptional regulation

Identifiers

PMID40298394
PMCPMC12090719

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.