Evidence map›Paper›PMID 40298317›Full record

ArticleJournal of the American Chemical Society2025

Dynamic Kinetic Asymmetric Hydroacylation: Racemization by Soft Enolization.

Mengfei Xu, Stephanie A Corio, Josephine M Warnica, Erin L Kuker, Alexander Lu, Jennifer S Hirschi, Vy M Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mengfei XuDepartment of Chemistry, University of California, Irvine, California 92697, United States.
Stephanie A CorioDepartment of Chemistry, Binghamton University, Binghamton, New York 13902, United States.
Josephine M WarnicaDepartment of Chemistry, University of California, Irvine, California 92697, United States.
Erin L KukerDepartment of Chemistry, University of California, Irvine, California 92697, United States.
Alexander LuDepartment of Chemistry, University of California, Irvine, California 92697, United States.
Jennifer S HirschiDepartment of Chemistry, Binghamton University, Binghamton, New York 13902, United States.ORCID 0000-0002-3470-0561
Vy M DongDepartment of Chemistry, University of California, Irvine, California 92697, United States.ORCID 0000-0002-8099-1048

Funding

Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular ProbesR35GM127071 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vy M Dong · 2018 to 2026
$4.9M
Mechanistic Investigation into Modern Catalytic ReactionsR35GM147183 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI Jennifer Hirschi · 2022 to 2026
$1.7M
NIGMS NIH HHS R35 GM127071NIGMS NIH HHS R35 GM147183
6 · The paper itself

Abstract

We report a dynamic kinetic asymmetric transformation (DyKAT) of racemic aldehydes by Rh-catalyzed hydroacylation of acrylamides. This intermolecular hydroacylation generates 1,4-ketoamides with high enantio- and diastereoselectivity. DFT and experimental studies provide mechanistic insights and reveal an unexpected Rh-catalyzed pathway for aldehyde racemization. Our study represents a pioneering kinetic resolution by intermolecular hydroacylation and contributes to the growing field of stereoconvergent catalysis featuring C-C bond construction.

Identifiers

PMID40298317
PMCPMC12082635

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.