ArticleJournal of feline medicine and surgery2025
Impact of interlaboratory differences on the measurement of serum creatinine and symmetric dimethylarginine values: does this affect clinical decision-making?
Article in Journal of feline medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- 2026 iCatCare consensus guidelines on the diagnosis and management of chronic kidney disease in cats.Journal of feline medicine and surgery · 2026Guideline
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectivesThis study aimed to assess the impact of interlaboratory differences (in analysis technique and reference intervals [RIs]) on the measurement of serum creatinine (sCr) and serum symmetric dimethylarginine (sSDMA) concentrations in cats and on classification by stage of chronic kidney disease (CKD).MethodsFor the interlaboratory discrepancy study, samples from 30 client-owned cats (healthy or diagnosed with CKD) with sCr in the range of 130-200 µmol/l and urine specific gravity <1.035 were retrospectively selected. A single batch of samples was analysed for sCr and sSDMA with one in-house laboratory machine and in three commercial laboratories. In addition, sCr values from 63 healthy cats aged ⩾10 years were used to calculate an age-specific RI for the in-house analyser.ResultsDespite a relatively good correlation (interclass correlation coefficient [ICC] = 0.875), the in-house analyser consistently reported lower sCr values, while for sSDMA, systematically higher values were obtained in one commercial laboratory (ICC = 0.707). A total of 22/30 (73%) cases had at least one laboratory reporting inconsistent sSDMA values in relation to the RI, and 23/30 (77%) for sCr. For subsequent staging using sSDMA, at least 1/4 laboratories indicated a different stage in 22/30 (73%) cases. For sCr, all laboratories classified the cats as stage 2; however, the in-house analyser classified 8/30 (27%) cats as stage 1. The RI (71-212 µmol/l) provided by the company for sCr measurement on the in-house machine was subsequently recalculated, resulting in a considerably lower upper limit (163 µmol/l) and a significantly (adjusted
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