Evidence map›Paper›PMID 40298279›Full record

ArticleCell proliferation2025

Synergistical Induction of Apoptosis via Cold Atmospheric Plasma and Nanohydroxyapatite for Selective Inhibition of Oral Squamous Cell Carcinoma in Tumour Microenvironment.

Wenting Qi, Hanghang Liu, Huaze Liu, Yuxuan Guo, Li Wu, Chongyun Bao, Xian Liu

Abstract read
In one paragraph

Article in Cell proliferation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenting QiState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Hanghang LiuState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People's Republic of China.ORCID https://orcid.org/0000-0001-6417-4091
Huaze LiuState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Yuxuan GuoState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Li WuInstitute of Applied Electromagnetics, College of Electronics and Information Engineering, Sichuan University, Chengdu, Sichuan, People's Republic of China.ORCID https://orcid.org/0000-0003-4481-1051
Chongyun BaoState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People's Republic of China.ORCID https://orcid.org/0000-0002-2570-9302
Xian LiuState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People's Republic of China.ORCID https://orcid.org/0000-0001-7792-9684

Funding

Institutional Research Fund of Sichuan University 2023SCUH0003National Natural Science Foundation of China 82371013National Natural Science Foundation of China 82401072Natural Science Foundation of Sichuan Province 2023NSFSC0707Natural Science Foundation of Sichuan Province 2024NSFSC0536Research and Develop Program, West China Hospital of Stomatology, Sichuan University RD-03-202306the Med-X Innovation Programme of the Med-X Center for Materials, Sichuan University MCM202301
6 · The paper itself

Abstract

Surgical resection, radiotherapy and chemotherapy are the primary strategies of treating cancers globally. However, the current treatment methods bring new disease burdens to patients due to postoperative complications and multiple side effects, especially in surface tumours such as oral squamous cell carcinoma (OSCC). In this study, we developed a microwave cold atmospheric plasma (CAP) device in conjunction with tumour microenvironment-responsive nanohydroxyapatite (nHA) for the first time. The synergistic effects of CAP and nHA combined application on OSCC were evaluated in both in vitro and in vivo experiments. The synergistic effects of CAP and pH-responsive NH

Indexed as

ApoptosisCarcinoma, Squamous CellDurapatiteMouth NeoplasmsNanoparticlesPlasma GasesTumor MicroenvironmentAnimalsCalciumCell Line, TumorHumansMiceMice, Inbred BALB CMice, NudeOxidative StressReactive Oxygen SpeciesCalciumDurapatitePlasma GasesReactive Oxygen Speciesapoptosiscalciumcold atmospheric plasmananohydroxyapatiteoral squamous cell carcinomareactive oxygen species

Identifiers

PMID40298279
PMCPMC12508692

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.