Evidence map›Paper›PMID 40298189›Full record

ReviewCancer medicine2025

The Roles of Exosomes in Anti-Cancer Drugs.

Panpan Feng, Xiaodong Zhang, Jian Gao, Lei Jiang, Yan Li

Abstract readReview
In one paragraph

Review in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Panpan FengDepartment of Radiotherapy, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Xiaodong ZhangDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Jian GaoScience Experiment Center of China Medical University, Shenyang, China.
Lei JiangDepartment of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Yan LiDepartment of Radiotherapy, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.ORCID https://orcid.org/0000-0001-5570-277X

Funding

National Natural Science Foundation of China 82103650Natural Science Foundation of Beijing Municipality 7214219The Capital Medical University Natural Science Foundation PYZ20143The Natural Science Foundation of The First Affiliated Hospital of Jinzhou Medical University KYTD-2022012
6 · The paper itself

Abstract

backgroundCancer is an escalating global health issue, with rising incidence rates annually. Chemotherapy, a primary cancer treatment, often exhibits low tumor-targeting efficiency and severe side effects, limiting its effectiveness. Recent research indicates that exosomes, due to their immunogenicity and molecular delivery capabilities, hold significant potential as drug carriers for tumor treatment.

methodsThis review summarizes the current status, powerful therapeutic potential, and challenges of using exosomes for the treatment of tumors.

resultsExosomes are crucial in tumor diagnosis, onset, and progression. To improve the efficacy of exosome-based treatments, researchers are exploring various biological, physical, and chemical approaches to engineer exosomes as a new nanomedicine translational therapy platform with broad and alterable therapeutic capabilities. Numerous clinical trials are currently underway investigating the safety and tolerability of exosomes carrying drugs to specific sites for the treatment of tumors.

conclusionsExosomes can be engineered as carriers to deliver therapeutic molecules to specific cells and tissues, offering a novel approach for disease treatment.

Indexed as

Antineoplastic AgentsDrug CarriersExosomesNeoplasmsAnimalsDrug Delivery SystemsHumansAntineoplastic AgentsDrug Carrierscancerchemotherapydrug carrierexosome

Identifiers

PMID40298189
PMCPMC12038748

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.