Evidence map›Paper›PMID 40298143›Full record

ArticlePain management2025

Dextrose-based Lyftogt perineural injection therapy on facial muscle strength in a Bell's palsy patient - a case report.

Isabel Patricia Serrano, Daniel Wang, Rochelle Angelica A Saratan, Melecio Iii Peña, Jeimylo C de Castro

Abstract readCase Reports
In one paragraph

Article in Pain management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isabel Patricia SerranoDepartment of Physical Medicine and Rehabilitation, The Medical City Ortigas, Pasig, Philippines.
Daniel WangMiller School of Medicine, University of Miami, Miami, FL, USA.
Rochelle Angelica A SaratanDepartment of Physical Medicine and Rehabilitation, The Medical City Ortigas, Pasig, Philippines.
Melecio Iii PeñaDepartment of Physical Medicine and Rehabilitation, The Medical City Ortigas, Pasig, Philippines.
Jeimylo C de CastroSMARTMD Center for Non-Surgical Pain Interventions, Makati, Philippines.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bell's palsy, a unilateral peripheral facial nerve palsy, is one of the most common acute mononeuropathies. Chronic cases persisting beyond one year present significant challenges to conventional treatment methods. Standard treatment includes steroids and antiviral medications in the acute phase, and physical therapy, various supplements such as vitamin B12 and folic acid supplementation, and injections for chronic therapy. This case report describes the effect of a unique treatment, dextrose-based Lyftogt perineural injection therapy (LPIT), in a 22-year-old Filipino male with left-sided peripheral facial nerve palsy. His condition had persisted for a duration of 13 months and was refractory to standard management. LPIT was delivered at chronic constriction points and endpoints of the facial nerve in ten different sessions. The mechanism of LPIT involves addressing glycopenia in affected nerves, reducing neurogenic inflammation, and facilitating nerve repair by enhancing the flow of nerve growth factors. Following treatment, marked improvement was observed in the functional muscle strength of the left occipitofrontalis, zygomaticus, and buccinator muscles, progressing from weak functional to functional. This case underscores LPIT's potential as an adjunct therapy for chronic Bell's palsy, adding to the limited but a growing body of evidence supporting its role in managing neuropathic conditions.

Indexed as

Bell PalsyFacial MusclesGlucoseMuscle StrengthHumansMaleYoung AdultGlucoseBell’s palsydextrosefacial nerve palsyinjectionslyftogt

Identifiers

PMID40298143
PMCPMC12118416

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.