Evidence map›Paper›PMID 40298074›Full record

SynthesisOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2025

Surgical Outcomes Comparison of Spontaneous Middle Cranial Fossa Cerebrospinal Fluid Leaks: Systematic Review and Meta-analysis.

Dimitrios Spinos, Panagiotis Varoutis, Georgios Geropoulos, Georgios Vavoulis, Georgios Georgountzos, Nina Rafailia Karela, Manthia Papageorgakopoulou, Kyriacos Evangelou, Jameel Muzaffar, Wai Sum Cho

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Risk Reduction of Recurrent Cerebrospinal Fluid Leaks With Postoperative Intracranial Pressure Management: A Systematic Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dimitrios SpinosDepartment of Cancer and Genomics, School of Medicine, University of Birmingham, Birmingham, UK.
Panagiotis VaroutisDepartment of Neurosurgery, General Hospital of Thessaloniki Ippokratio, Thessaloniki, Thessaloniki, Greece.
Georgios GeropoulosWest Hertfordshire Teaching Hospitals, Watford, UK.
Georgios VavoulisDepartment of Neurosurgery, General Attica Hospital "KAT", Athens, Greece.
Georgios GeorgountzosDepartment of Neurosurgery, General Hospital of Nikaia "Agios Panteleimon", Athens, Greece.
Nina Rafailia KarelaDepartment of Neurosurgery, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.
Manthia PapageorgakopoulouSchool of Medicine, University of Patras, Patras, Patras, Greece.
Kyriacos EvangelouSchool of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Jameel MuzaffarDepartment of Otolaryngology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Wai Sum ChoDepartment of Otolaryngology, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSpontaneous cerebrospinal fluid (sCSF) leaks of lateral skull base have little consensus on optimal management. We synthesized and evaluated current literature via systematic and meta-analysis to compare the success rates and complications of the different surgical techniques for middle cranial fossa (MCF) sCSF leak repair. DATA SOURCES: MEDLINE, EMBASE, and Cochrane Library. REVIEW

methodsStudies selected concerned surgical treatment of MCF sCSF leak. Data extracted included the following: study characteristics, patient characteristics, primary outcomes, and secondary outcomes.

resultsFrom 297 repairs with a MCF approach, the complication rate was 16.2% (95% CI: 12.3%-21.1%, I

conclusionThere is no statistically significant difference in the outcomes of repair techniques. Decision making for the preferred approach will be dependent on the location, size and number of the defects, hearing status, and in consultation with the patient.

Indexed as

Cerebrospinal Fluid LeakCranial Fossa, MiddleHumansTreatment Outcomecerebrospinal fluidmeta‐analysismiddle cranial fossaskull basetemporal bone

Identifiers

PMID40298074
PMCPMC12207348

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.