ArticleClinical endocrinology2025
Elevated Triglyceride-Glucose Index Is Associated With Insulin Resistance, Metabolic Syndrome Components, Nonalcoholic Fatty Liver Disease, and Adverse Pregnancy Outcomes in Chinese Women With Polycystic Ovary Syndrome.
Article in Clinical endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The correlation between triglyceride-glucose index in early pregnancy (<20 weeks) and pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Interaction between triglyceride-glucose index and body mass index on pregnancy loss in Chinese women with polycystic ovary syndrome: a secondary analysis of a randomized clinical trial.Reproductive biology and endocrinology : RB&E · 2026Article
- The association between triglyceride glucose-body mass index and live birth outcomes in women with clinical pregnancy after frozen-thawed embryo transfer: a cohort study.BMC pregnancy and childbirth · 2026Article
- The Cut-Off for Triglyceride-Glucose-Body Mass Index (TyG-BMI) and Triglyceride-Glucose-Waist Circumference Index (TyG-WC) Discriminating the Insulin Resistance Based on the SHBG Level and HOMA-IR Value in Caucasian Women with Polycystic Ovary Syndrome.Medicina (Kaunas, Lithuania) · 2026Article
- Combined metabolic-reproductive association and predictive value of AMH and TyG index in PCOS: a single-center retrospective study.Frontiers in endocrinology · 2026Article
- First-trimester atherogenic index of plasma and triglyceride-glucose indices in pregestational diabetes mellitus: associations with adverse pregnancy outcomes.BMC pregnancy and childbirth · 2025Article
- The effect of longitudinal trajectories of triglyceride-glucose index on the incident metabolic dysfunction-associated steatotic liver disease.BMC gastroenterology · 2025Article
- The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases.Cardiovascular diabetology · 2025Review
- The predictive value of the metabolic score for insulin resistance for metabolism-related disorders and fertility outcomes in Chinese women with polycystic ovary syndrome.Frontiers in endocrinology · 2025Article
- Comment on "Association Between Triglyceride-Glucose Index and Malignant Risk in Thyroid Nodules: A Cross-Sectional Analysis" [Letter].Journal of inflammation research · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
aimTo investigate the associations of triglyceride-glucose index (TyG) with anthropometric characteristics, metabolic/endocrine profiles, and pregnancy outcomes in Chinese women with polycystic ovary syndrome (PCOS).
methodsThis secondary analysis of the Acupuncture and Clomiphene for Chinese Women with Polycystic Ovary Syndrome trial (PCOSAct) included 956 participants with prospectively collected data. TyG was calculated using fasting triglyceride and glucose levels (Ln [TG (mg/dL) × FPG (mg/dL)/2]). Linear regression and trend analyses evaluated relationships between TyG and clinical parameters. Receiver operating characteristic (ROC) curves assessed TyG's predictive capacity for insulin resistance (IR), metabolic syndrome (MS), and nonalcoholic fatty liver disease (NAFLD). Multivariable logistic regression estimated risks for metabolic outcomes and pregnancy outcomes.
resultsLinear trends revealed that the TyG was positively associated with age, body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio, systolic blood pressure, diastolic blood pressure, FPG, fasting insulin, the homeostatic model assessment for insulin resistance (HOMA-IR), total cholesterol, triglycerides, low-density lipoprotein (LDL), apolipoprotein B, free androgen index, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and the prevalence of IR, MS, and NAFLD across various standards. Conversely, TyG was negatively correlated with the quantitative insulin sensitivity check index (QUICKI), high-density lipoprotein (HDL), apolipoprotein A1, sex hormone-binding globulin (SHBG), and the prevalence of ovulation per cycle, conception, pregnancy, and live birth. After adjusting for age and BMI, a significant linear relationship was observed between TyG and components of MS, IR markers, and ALT. The ROC curve analysis indicated that the AUC
conclusionsElevated TyG index strongly associates with adverse metabolic trajectories, and adverse pregnancy outcomes in PCOS patients. This biomarker shows particular utility for identifying metabolic dysfunction, suggesting clinical potential for risk stratification in PCOS management.
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