Trial reportArthritis care & research2025
Moderators and Mediators of Pain and Function Outcomes in a New Service Delivery Model for Management of Knee Osteoarthritis in Primary Care: Secondary Exploratory Analysis of a Randomized Controlled Trial.
Trial report in Arthritis care & research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
objectiveOur objective was to explore moderators and mediators influenced changes in pain and function in people with knee osteoarthritis (OA) receiving a new model of primary care service delivery (Optimizing Primary Care Management of Knee Osteoarthritis [PARTNER]), at 12 months (ACTRN: 12617001595303).
methodsThis was a secondary analyses of a cluster randomized controlled trial comparing PARTNER to the usual general practitioner-delivered care (n = 217 patients: 112 PARTNER patients and 105 usual care patients) on knee pain and function. Pain was measured using a numerical rating scale (range 0-10, with a higher score indicating more severe pain), and function was measured using the function subscale of the Knee Injury and Osteoarthritis Outcome Score (range 0-100, with a higher score indicating better outcome). Baseline variables selected as potential moderators included age, sex, body mass index, pain duration, residential state, living arrangements, education, employment status, back pain, and other joint issues. Mediation variables included physical activity, fear of movement, pain catastrophizing, OA self-management, self-efficacy, sleep, fatigue, quality of life, depression, and satisfaction.
resultsFor change in pain, no moderators influenced the intervention effect. However, age moderated change in function, with intervention participants <50 years demonstrating greater functional improvement than their older counterparts, compared to the control group (50-69 years: coefficient -32.88, 95% confidence interval [CI] -45.02 to -20.74; ≥70 years: coefficient -24.28, 95% CI -36.53 to -12.02). Mediation analysis revealed significant indirect effects of overall, treatment-related, and symptom-related satisfaction on mean change in pain (-0.10, -0.06, and -0.08, respectively) and function (0.09, 0.05, and 0.07, respectively).
conclusionYounger PARTNER participants showed greater functional improvement compared to older age groups (moderating effect). Additionally, indirect mediation effects suggest increased satisfaction across the three satisfaction domains led to reduced knee pain and enhanced function.
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